Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM043768-07
Application #
2182173
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1990-04-01
Project End
1999-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Massachusetts Medical School Worcester
Department
Biochemistry
Type
Schools of Medicine
DUNS #
660735098
City
Worcester
State
MA
Country
United States
Zip Code
01655
Lu, Hua; Fermaintt, Charles S; Cherepanova, Natalia A et al. (2018) Mammalian STT3A/B oligosaccharyltransferases segregate N-glycosylation at the translocon from lipid-linked oligosaccharide hydrolysis. Proc Natl Acad Sci U S A 115:9557-9562
Rinis, Natalia; Golden, Jennifer E; Marceau, Caleb D et al. (2018) Editing N-Glycan Site Occupancy with Small-Molecule Oligosaccharyltransferase Inhibitors. Cell Chem Biol 25:1231-1241.e4
Wei, Wei; Misra, Saurav; Cannon, Matthew V et al. (2018) Molecular mechanisms of missense mutations that generate ectopic N-glycosylation sites in coagulation factor VIII. Biochem J 475:873-886
Shrimal, Shiteshu; Cherepanova, Natalia A; Gilmore, Reid (2017) DC2 and KCP2 mediate the interaction between the oligosaccharyltransferase and the ER translocon. J Cell Biol 216:3625-3638
Lin, David L; Cherepanova, Natalia A; Bozzacco, Leonia et al. (2017) Dengue Virus Hijacks a Noncanonical Oxidoreductase Function of a Cellular Oligosaccharyltransferase Complex. MBio 8:
Shrimal, Shiteshu; Cherepanova, Natalia A; Gilmore, Reid (2017) One flexible loop in OST lassos both substrates. Nat Struct Mol Biol 24:1009-1010
Cherepanova, Natalia; Shrimal, Shiteshu; Gilmore, Reid (2016) N-linked glycosylation and homeostasis of the endoplasmic reticulum. Curr Opin Cell Biol 41:57-65
Cherepanova, Natalia A; Gilmore, Reid (2016) Mammalian cells lacking either the cotranslational or posttranslocational oligosaccharyltransferase complex display substrate-dependent defects in asparagine linked glycosylation. Sci Rep 6:20946
Lopez-Sambrooks, Cecilia; Shrimal, Shiteshu; Khodier, Carol et al. (2016) Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells. Nat Chem Biol 12:1023-1030
Shrimal, Shiteshu; Gilmore, Reid (2015) Reduced expression of the oligosaccharyltransferase exacerbates protein hypoglycosylation in cells lacking the fully assembled oligosaccharide donor. Glycobiology 25:774-83

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