Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM043880-07
Application #
2182250
Study Section
Physiological Chemistry Study Section (PC)
Project Start
1990-04-01
Project End
1998-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Georgetown University
Department
Biochemistry
Type
Schools of Dentistry
DUNS #
049515844
City
Washington
State
DC
Country
United States
Zip Code
20057
Stockstill, Katherine; Doyle, Timothy M; Yan, Xisheng et al. (2018) Dysregulation of sphingolipid metabolism contributes to bortezomib-induced neuropathic pain. J Exp Med 215:1301-1313
Montefusco, David J; Allegood, Jeremy C; Spiegel, Sarah et al. (2018) Non-alcoholic fatty liver disease: Insights from sphingolipidomics. Biochem Biophys Res Commun 504:608-616
Shaw, Jeremy; Costa-Pinheiro, Pedro; Patterson, Logan et al. (2018) Novel Sphingolipid-Based Cancer Therapeutics in the Personalized Medicine Era. Adv Cancer Res 140:327-366
Geffken, Kurt; Spiegel, Sarah (2018) Sphingosine kinase 1 in breast cancer. Adv Biol Regul 67:59-65
Vrzalikova, K; Ibrahim, M; Vockerodt, M et al. (2018) S1PR1 drives a feedforward signalling loop to regulate BATF3 and the transcriptional programme of Hodgkin lymphoma cells. Leukemia 32:214-223
Newton, Jason; Milstien, Sheldon; Spiegel, Sarah (2018) Niemann-Pick type C disease: The atypical sphingolipidosis. Adv Biol Regul 70:82-88
Booth, Laurence; Roberts, Jane L; Spiegel, Sarah et al. (2018) Fingolimod augments Pemetrexed killing of non-small cell lung cancer and overcomes resistance to ERBB inhibition. Cancer Biol Ther :1-11
Lima, Santiago; Takabe, Kazuaki; Newton, Jason et al. (2018) TP53 is required for BECN1- and ATG5-dependent cell death induced by sphingosine kinase 1 inhibition. Autophagy 14:942-957
Maczis, Melissa A; Maceyka, Michael; Waters, Michael R et al. (2018) Sphingosine kinase 1 activation by estrogen receptor ?36 contributes to tamoxifen resistance in breast cancer. J Lipid Res 59:2297-2307
Lima, Santiago; Milstien, Sheldon; Spiegel, Sarah (2017) Sphingosine and Sphingosine Kinase 1 Involvement in Endocytic Membrane Trafficking. J Biol Chem 292:3074-3088

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