Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
2R01GM043893-06
Application #
2182261
Study Section
Molecular Cytology Study Section (CTY)
Project Start
1991-01-01
Project End
1996-07-31
Budget Start
1996-01-01
Budget End
1996-07-31
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Chicago
Department
Genetics
Type
Schools of Medicine
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637
Rosenbaum, Joel C; Fredrickson, Eric K; Oeser, Michelle L et al. (2011) Disorder targets misorder in nuclear quality control degradation: a disordered ubiquitin ligase directly recognizes its misfolded substrates. Mol Cell 41:93-106
Veatch, Joshua R; McMurray, Michael A; Nelson, Zara W et al. (2009) Mitochondrial dysfunction leads to nuclear genome instability via an iron-sulfur cluster defect. Cell 137:1247-58
Henderson, Kiersten A; Gottschling, Daniel E (2008) A mother's sacrifice: what is she keeping for herself? Curr Opin Cell Biol 20:723-8
Gardner, Richard G; Nelson, Zara W; Gottschling, Daniel E (2005) Degradation-mediated protein quality control in the nucleus. Cell 120:803-15
Gardner, Richard G; Nelson, Zara W; Gottschling, Daniel E (2005) Ubp10/Dot4p regulates the persistence of ubiquitinated histone H2B: distinct roles in telomeric silencing and general chromatin. Mol Cell Biol 25:6123-39
Stellwagen, Anne E; Haimberger, Zara W; Veatch, Joshua R et al. (2003) Ku interacts with telomerase RNA to promote telomere addition at native and broken chromosome ends. Genes Dev 17:2384-95
McMurray, Michael A; Gottschling, Daniel E (2003) An age-induced switch to a hyper-recombinational state. Science 301:1908-11
van Leeuwen, Fred; Gafken, Philip R; Gottschling, Daniel E (2002) Dot1p modulates silencing in yeast by methylation of the nucleosome core. Cell 109:745-56
Kelly, T J; Qin, S; Gottschling, D E et al. (2000) Type B histone acetyltransferase Hat1p participates in telomeric silencing. Mol Cell Biol 20:7051-8
Huang, H; Kahana, A; Gottschling, D E et al. (1997) The ubiquitin-conjugating enzyme Rad6 (Ubc2) is required for silencing in Saccharomyces cerevisiae. Mol Cell Biol 17:6693-9

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