Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM044191-07
Application #
2182419
Study Section
Metallobiochemistry Study Section (BMT)
Project Start
1990-04-01
Project End
1999-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Brandeis University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
616845814
City
Waltham
State
MA
Country
United States
Zip Code
02454
Asciutto, Eliana K; Pochapsky, Thomas C (2018) Some Surprising Implications of NMR-directed Simulations of Substrate Recognition and Binding by Cytochrome P450cam (CYP101A1). J Mol Biol 430:1295-1310
Pochapsky, Thomas C; Wong, Nathan; Zhuang, Yihao et al. (2018) NADH reduction of nitroaromatics as a probe for residual ferric form high-spin in a cytochrome P450. Biochim Biophys Acta Proteins Proteom 1866:126-133
Tietz, Drew R; Podust, Larissa M; Sherman, David H et al. (2017) Solution Conformations and Dynamics of Substrate-Bound Cytochrome P450 MycG. Biochemistry 56:2701-2714
Tietz, Drew R; Colthart, Allison M; Sondej Pochapsky, Susan et al. (2017) Substrate recognition by two different P450s: Evidence for conserved roles in a common fold. Sci Rep 7:13581
Deshpande, Aditi R; Pochapsky, Thomas C; Ringe, Dagmar (2017) The Metal Drives the Chemistry: Dual Functions of Acireductone Dioxygenase. Chem Rev 117:10474-10501
Colthart, Allison M; Tietz, Drew R; Ni, Yuhua et al. (2016) Detection of substrate-dependent conformational changes in the P450 fold by nuclear magnetic resonance. Sci Rep 6:22035
Pochapsky, Thomas C (2014) Examining how enzymes self-organize in a membrane. Proc Natl Acad Sci U S A 111:3659-60
Li, Shengying; Tietz, Drew R; Rutaganira, Florentine U et al. (2012) Substrate recognition by the multifunctional cytochrome P450 MycG in mycinamicin hydroxylation and epoxidation reactions. J Biol Chem 287:37880-90
Asciutto, Eliana K; Young, Matthew J; Madura, Jeffry et al. (2012) Solution structural ensembles of substrate-free cytochrome P450(cam). Biochemistry 51:3383-93
Friedman, Erin J; Wang, Helen X; Jiang, Kun et al. (2011) Acireductone dioxygenase 1 (ARD1) is an effector of the heterotrimeric G protein beta subunit in Arabidopsis. J Biol Chem 286:30107-18

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