Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM044589-07
Application #
2182601
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1990-09-29
Project End
1999-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Cavolo, Samantha L; Zhou, Chaoming; Ketcham, Stephanie A et al. (2015) Mycalolide B dissociates dynactin and abolishes retrograde axonal transport of dense-core vesicles. Mol Biol Cell 26:2664-72
Day, Charles A; Baetz, Nicholas W; Copeland, Courtney A et al. (2015) Microtubule motors power plasma membrane tubulation in clathrin-independent endocytosis. Traffic 16:572-90
Chowdhury, Saikat; Ketcham, Stephanie A; Schroer, Trina A et al. (2015) Structural organization of the dynein-dynactin complex bound to microtubules. Nat Struct Mol Biol 22:345-7
Imai, Hiroshi; Narita, Akihiro; Maéda, Yuichiro et al. (2014) Dynactin 3D structure: implications for assembly and dynein binding. J Mol Biol 426:3262-3271
Cheong, Frances Ka Yan; Feng, Lijuan; Sarkeshik, Ali et al. (2014) Dynactin integrity depends upon direct binding of dynamitin to Arp1. Mol Biol Cell 25:2171-80
Yeh, Ting-Yu; Kowalska, Anna K; Scipioni, Brett R et al. (2013) Dynactin helps target Polo-like kinase 1 to kinetochores via its left-handed beta-helical p27 subunit. EMBO J 32:1023-35
DeBerg, Hannah A; Blehm, Benjamin H; Sheung, Janet et al. (2013) Motor domain phosphorylation modulates kinesin-1 transport. J Biol Chem 288:32612-21
Wang, Shusheng; Ketcham, Stephanie A; Schön, Arne et al. (2013) Nudel/NudE and Lis1 promote dynein and dynactin interaction in the context of spindle morphogenesis. Mol Biol Cell 24:3522-33
Blehm, Benjamin H; Schroer, Trina A; Trybus, Kathleen M et al. (2013) In vivo optical trapping indicates kinesin's stall force is reduced by dynein during intracellular transport. Proc Natl Acad Sci U S A 110:3381-6
Yeh, Ting-Yu; Quintyne, Nicholas J; Scipioni, Brett R et al. (2012) Dynactin's pointed-end complex is a cargo-targeting module. Mol Biol Cell 23:3827-37

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