Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM044619-06
Application #
2182625
Study Section
Molecular Biology Study Section (MBY)
Project Start
1991-05-01
Project End
1999-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Newman, Martin A; Ji, Fei; Fischer, Sylvia E J et al. (2018) The surveillance of pre-mRNA splicing is an early step in C. elegans RNAi of endogenous genes. Genes Dev 32:670-681
Ambros, Victor; Ruvkun, Gary (2018) Recent Molecular Genetic Explorations of Caenorhabditis elegans MicroRNAs. Genetics 209:651-673
Dowen, Robert H; Breen, Peter C; Tullius, Thomas et al. (2016) A microRNA program in the C. elegans hypodermis couples to intestinal mTORC2/PQM-1 signaling to modulate fat transport. Genes Dev 30:1515-28
Phillips, Carolyn M; Brown, Kristen C; Montgomery, Brooke E et al. (2015) piRNAs and piRNA-Dependent siRNAs Protect Conserved and Essential C. elegans Genes from Misrouting into the RNAi Pathway. Dev Cell 34:457-65
Phillips, Carolyn M; Montgomery, Brooke E; Breen, Peter C et al. (2014) MUT-14 and SMUT-1 DEAD box RNA helicases have overlapping roles in germline RNAi and endogenous siRNA formation. Curr Biol 24:839-44
Shi, Zhen; Hayes, Gabriel; Ruvkun, Gary (2013) Dual regulation of the lin-14 target mRNA by the lin-4 miRNA. PLoS One 8:e75475
Tabach, Yuval; Billi, Allison C; Hayes, Gabriel D et al. (2013) Identification of small RNA pathway genes using patterns of phylogenetic conservation and divergence. Nature 493:694-8
Shi, Zhen; Montgomery, Taiowa A; Qi, Yan et al. (2013) High-throughput sequencing reveals extraordinary fluidity of miRNA, piRNA, and siRNA pathways in nematodes. Genome Res 23:497-508
Tabach, Yuval; Golan, Tamar; Hernández-Hernández, Abrahan et al. (2013) Human disease locus discovery and mapping to molecular pathways through phylogenetic profiling. Mol Syst Biol 9:692
Fischer, Sylvia E J; Pan, Qi; Breen, Peter C et al. (2013) Multiple small RNA pathways regulate the silencing of repeated and foreign genes in C. elegans. Genes Dev 27:2678-95

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