Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM044853-06
Application #
2182813
Study Section
Special Emphasis Panel (ZRG3-PB (01))
Project Start
1990-08-31
Project End
1999-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Harvard University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
071723621
City
Cambridge
State
MA
Country
United States
Zip Code
02138
Sung, Rou-Jia; Zhang, Michael; Qi, Yan et al. (2013) Structural and biochemical analysis of DNA helix invasion by the bacterial 8-oxoguanine DNA glycosylase MutM. J Biol Chem 288:10012-23
Didovyk, Andriy; Verdine, Gregory L (2012) Structural origins of DNA target selection and nucleobase extrusion by a DNA cytosine methyltransferase. J Biol Chem 287:40099-105
Qi, Yan; Nam, Kwangho; Spong, Marie C et al. (2012) Strandwise translocation of a DNA glycosylase on undamaged DNA. Proc Natl Acad Sci U S A 109:1086-91
Crenshaw, Charisse M; Nam, Kwangho; Oo, Kimberly et al. (2012) Enforced presentation of an extrahelical guanine to the lesion recognition pocket of human 8-oxoguanine glycosylase, hOGG1. J Biol Chem 287:24916-28
Gude, Lourdes; Berkovitch, Shaunna S; Santos, Webster L et al. (2012) Mapping targetable sites on human telomerase RNA pseudoknot/template domain using 2'-OMe RNA-interacting polynucleotide (RIPtide) microarrays. J Biol Chem 287:18843-53
Sung, Rou-Jia; Zhang, Michael; Qi, Yan et al. (2012) Sequence-dependent structural variation in DNA undergoing intrahelical inspection by the DNA glycosylase MutM. J Biol Chem 287:18044-54
Qi, Yan; Spong, Marie C; Nam, Kwangho et al. (2010) Entrapment and structure of an extrahelical guanine attempting to enter the active site of a bacterial DNA glycosylase, MutM. J Biol Chem 285:1468-78
Bowman, Brian R; Lee, Seongmin; Wang, Shuyu et al. (2010) Structure of Escherichia coli AlkA in complex with undamaged DNA. J Biol Chem 285:35783-91
Qi, Yan; Spong, Marie C; Nam, Kwangho et al. (2009) Encounter and extrusion of an intrahelical lesion by a DNA repair enzyme. Nature 462:762-6
Blainey, Paul C; Luo, Guobin; Kou, S C et al. (2009) Nonspecifically bound proteins spin while diffusing along DNA. Nat Struct Mol Biol 16:1224-9

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