Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM044944-07
Application #
2182883
Study Section
Pharmacology A Study Section (PHRA)
Project Start
1991-07-01
Project End
1999-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Thomas Jefferson University
Department
Pharmacology
Type
Schools of Medicine
DUNS #
061197161
City
Philadelphia
State
PA
Country
United States
Zip Code
19107

  Publications

Chaturvedi, Madhu; Schilling, Justin; Beautrait, Alexandre et al. (2018) Emerging Paradigm of Intracellular Targeting of G Protein-Coupled Receptors. Trends Biochem Sci 43:533-546
Komolov, Konstantin E; Benovic, Jeffrey L (2018) G protein-coupled receptor kinases: Past, present and future. Cell Signal 41:17-24
Luo, Jiansong; Busillo, John M; Stumm, Ralf et al. (2017) G Protein-Coupled Receptor Kinase 3 and Protein Kinase C Phosphorylate the Distal C-Terminal Tail of the Chemokine Receptor CXCR4 and Mediate Recruitment of ?-Arrestin. Mol Pharmacol 91:554-566
Wang, Jianjun; Luo, Jiansong; Aryal, Dipendra K et al. (2017) G protein-coupled receptor kinase-2 (GRK-2) regulates serotonin metabolism through the monoamine oxidase AMX-2 in Caenorhabditis elegans. J Biol Chem 292:5943-5956
Komolov, Konstantin E; Du, Yang; Duc, Nguyen Minh et al. (2017) Structural and Functional Analysis of a ?2-Adrenergic Receptor Complex with GRK5. Cell 169:407-421.e16
DeRita, Rachel M; Zerlanko, Brad; Singh, Amrita et al. (2017) c-Src, Insulin-Like Growth Factor I Receptor, G-Protein-Coupled Receptor Kinases and Focal Adhesion Kinase are Enriched Into Prostate Cancer Cell Exosomes. J Cell Biochem 118:66-73
Komolov, Konstantin E; Bhardwaj, Anshul; Benovic, Jeffrey L (2015) Atomic Structure of GRK5 Reveals Distinct Structural Features Novel for G Protein-coupled Receptor Kinases. J Biol Chem 290:20629-47
Kang, Dong Soo; Tian, Xufan; Benovic, Jeffrey L (2014) Role of ?-arrestins and arrestin domain-containing proteins in G protein-coupled receptor trafficking. Curr Opin Cell Biol 27:63-71
Carr 3rd, Richard; Du, Yang; Quoyer, Julie et al. (2014) Development and characterization of pepducins as Gs-biased allosteric agonists. J Biol Chem 289:35668-84
Quoyer, Julie; Janz, Jay M; Luo, Jiansong et al. (2013) Pepducin targeting the C-X-C chemokine receptor type 4 acts as a biased agonist favoring activation of the inhibitory G protein. Proc Natl Acad Sci U S A 110:E5088-97

Showing the most recent 10 out of 126 publications