Sherrer, Shanen M; Penland, Elisabeth; Modrich, Paul (2018) The mutagen and carcinogen cadmium is a high-affinity inhibitor of the zinc-dependent MutL? endonuclease. Proc Natl Acad Sci U S A 115:7314-7319
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Genschel, Jochen; Kadyrova, Lyudmila Y; Iyer, Ravi R et al. (2017) Interaction of proliferating cell nuclear antigen with PMS2 is required for MutL? activation and function in mismatch repair. Proc Natl Acad Sci U S A 114:4930-4935
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Chen, Yu-Tsung Shane; Wu, Jianhong; Modrich, Paul et al. (2016) The C-terminal 20 Amino Acids of Drosophila Topoisomerase 2 Are Required for Binding to a BRCA1 C Terminus (BRCT) Domain-containing Protein, Mus101, and Fidelity of DNA Segregation. J Biol Chem 291:13216-28
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Modrich, Paul (2016) Mechanisms in E. coli and Human Mismatch Repair (Nobel Lecture). Angew Chem Int Ed Engl 55:8490-501
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Qiu, Ruoyi; Sakato, Miho; Sacho, Elizabeth J et al. (2015) MutL traps MutS at a DNA mismatch. Proc Natl Acad Sci U S A 112:10914-9
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Lindsey-Boltz, Laura A; Kemp, Michael G; Reardon, Joyce T et al. (2014) Coupling of human DNA excision repair and the DNA damage checkpoint in a defined in vitro system. J Biol Chem 289:5074-82
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Shao, Hongbing; Baitinger, Celia; Soderblom, Erik J et al. (2014) Hydrolytic function of Exo1 in mammalian mismatch repair. Nucleic Acids Res 42:7104-12
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Pluciennik, Anna; Burdett, Vickers; Baitinger, Celia et al. (2013) Extrahelical (CAG)/(CTG) triplet repeat elements support proliferating cell nuclear antigen loading and MutL? endonuclease activation. Proc Natl Acad Sci U S A 110:12277-82
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Tseng, Quincy; Orans, Jillian; Hast, Michael A et al. (2011) Purification, crystallization and preliminary X-ray diffraction analysis of the human mismatch repair protein MutS?. Acta Crystallogr Sect F Struct Biol Cryst Commun 67:947-52
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Liu, Yiyong; Kadyrov, Farid A; Modrich, Paul (2011) PARP-1 enhances the mismatch-dependence of 5'-directed excision in human mismatch repair in vitro. DNA Repair (Amst) 10:1145-53
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