Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
2R01GM046147-05
Application #
2183681
Study Section
Biochemistry Study Section (BIO)
Project Start
1992-09-30
Project End
2000-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Harvard University
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115
Kisselev, Alexei F; van der Linden, Wouter A; Overkleeft, Herman S (2012) Proteasome inhibitors: an expanding army attacking a unique target. Chem Biol 19:99-115
Kisselev, Alexei F; Callard, Alice; Goldberg, Alfred L (2006) Importance of the different proteolytic sites of the proteasome and the efficacy of inhibitors varies with the protein substrate. J Biol Chem 281:8582-90
Qiu, Xiao-Bo; Ouyang, Song-Ying; Li, Chao-Jun et al. (2006) hRpn13/ADRM1/GP110 is a novel proteasome subunit that binds the deubiquitinating enzyme, UCH37. EMBO J 25:5742-53
Lecker, Stewart H; Goldberg, Alfred L; Mitch, William E (2006) Protein degradation by the ubiquitin-proteasome pathway in normal and disease states. J Am Soc Nephrol 17:1807-19
Cascio, Paolo; Goldberg, Alfred L (2005) Preparation of hybrid (19S-20S-PA28) proteasome complexes and analysis of peptides generated during protein degradation. Methods Enzymol 398:336-52
Chang, Shih-Chung; Momburg, Frank; Bhutani, Nidhi et al. (2005) The ER aminopeptidase, ERAP1, trims precursors to lengths of MHC class I peptides by a ""molecular ruler"" mechanism. Proc Natl Acad Sci U S A 102:17107-12
Brignone, Chrystelle; Bradley, Kathleen E; Kisselev, Alexei F et al. (2004) A post-ubiquitination role for MDM2 and hHR23A in the p53 degradation pathway. Oncogene 23:4121-9
Benaroudj, Nadia; Zwickl, Peter; Seemuller, Erika et al. (2003) ATP hydrolysis by the proteasome regulatory complex PAN serves multiple functions in protein degradation. Mol Cell 11:69-78
Kisselev, Alexei F; Garcia-Calvo, Margarita; Overkleeft, Herman S et al. (2003) The caspase-like sites of proteasomes, their substrate specificity, new inhibitors and substrates, and allosteric interactions with the trypsin-like sites. J Biol Chem 278:35869-77
Huang, H C; Sherman, M Y; Kandror, O et al. (2001) The molecular chaperone DnaJ is required for the degradation of a soluble abnormal protein in Escherichia coli. J Biol Chem 276:3920-8

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