Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
2R01GM047274-04A1
Application #
2184667
Study Section
Metallobiochemistry Study Section (BMT)
Project Start
1992-04-01
Project End
1999-11-30
Budget Start
1995-12-13
Budget End
1996-11-30
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Michigan State University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
193247145
City
East Lansing
State
MI
Country
United States
Zip Code
48824

  Publications

Greene, Brandon L; Nocera, Daniel G; Stubbe, JoAnne (2018) Basis of dATP inhibition of RNRs. J Biol Chem 293:10413-10414
Greene, Brandon L; Stubbe, JoAnne; Nocera, Daniel G (2018) Photochemical Rescue of a Conformationally Inactivated Ribonucleotide Reductase. J Am Chem Soc 140:15744-15752
Guo, Junling; Suástegui, Miguel; Sakimoto, Kelsey K et al. (2018) Light-driven fine chemical production in yeast biohybrids. Science 362:813-816
Lee, Wankyu; Kasanmascheff, Müge; Huynh, Michael et al. (2018) Properties of Site-Specifically Incorporated 3-Aminotyrosine in Proteins To Study Redox-Active Tyrosines: Escherichia coli Ribonucleotide Reductase as a Paradigm. Biochemistry 57:3402-3415
Ravichandran, Kanchana; Minnihan, Ellen C; Lin, Qinghui et al. (2017) Glutamate 350 Plays an Essential Role in Conformational Gating of Long-Range Radical Transport in Escherichia coli Class Ia Ribonucleotide Reductase. Biochemistry 56:856-868
Greene, Brandon L; Taguchi, Alexander T; Stubbe, JoAnne et al. (2017) Conformationally Dynamic Radical Transfer within Ribonucleotide Reductase. J Am Chem Soc 139:16657-16665
Ravichandran, Kanchana R; Zong, Allan B; Taguchi, Alexander T et al. (2017) Formal Reduction Potentials of Difluorotyrosine and Trifluorotyrosine Protein Residues: Defining the Thermodynamics of Multistep Radical Transfer. J Am Chem Soc 139:2994-3004
Olshansky, Lisa; Greene, Brandon L; Finkbeiner, Chelsea et al. (2016) Photochemical Generation of a Tryptophan Radical within the Subunit Interface of Ribonucleotide Reductase. Biochemistry 55:3234-40
Olshansky, Lisa; Stubbe, JoAnne; Nocera, Daniel G (2016) Charge-Transfer Dynamics at the ?/? Subunit Interface of a Photochemical Ribonucleotide Reductase. J Am Chem Soc 138:1196-205
Ravichandran, Kanchana R; Taguchi, Alexander T; Wei, Yifeng et al. (2016) A >200 meV Uphill Thermodynamic Landscape for Radical Transport in Escherichia coli Ribonucleotide Reductase Determined Using Fluorotyrosine-Substituted Enzymes. J Am Chem Soc 138:13706-13716

Showing the most recent 10 out of 78 publications