Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM048661-04
Application #
2186169
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1993-07-01
Project End
1998-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Veterinary Sciences
Type
Schools of Veterinary Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Nirschl, Jeffrey J; Ghiretti, Amy E; Holzbaur, Erika L F (2017) The impact of cytoskeletal organization on the local regulation of neuronal transport. Nat Rev Neurosci 18:585-597
Klinman, Eva; Tokito, Mariko; Holzbaur, Erika L F (2017) CDK5-dependent activation of dynein in the axon initial segment regulates polarized cargo transport in neurons. Traffic 18:808-824
Ayloo, Swathi; Guedes-Dias, Pedro; Ghiretti, Amy E et al. (2017) Dynein efficiently navigates the dendritic cytoskeleton to drive the retrograde trafficking of BDNF/TrkB signaling endosomes. Mol Biol Cell 28:2543-2554
Nirschl, Jeffrey J; Holzbaur, Erika L F (2016) Live-cell imaging of retrograde transport initiation in primary neurons. Methods Cell Biol 131:269-76
Ghiretti, Amy E; Thies, Edda; Tokito, Mariko K et al. (2016) Activity-Dependent Regulation of Distinct Transport and Cytoskeletal Remodeling Functions of the Dendritic Kinesin KIF21B. Neuron 92:857-872
Nirschl, Jeffrey J; Magiera, Maria M; Lazarus, Jacob E et al. (2016) ?-Tubulin Tyrosination and CLIP-170 Phosphorylation Regulate the Initiation of Dynein-Driven Transport in Neurons. Cell Rep 14:2637-52
Twelvetrees, Alison E; Pernigo, Stefano; Sanger, Anneri et al. (2016) The Dynamic Localization of Cytoplasmic Dynein in Neurons Is Driven by Kinesin-1. Neuron 90:1000-15
Nirschl, Jeffrey J; Ghiretti, Amy E; Holzbaur, Erika L F (2016) Lipid Rafts Assemble Dynein Ensembles. Trends Biochem Sci 41:393-394
Ballister, Edward R; Ayloo, Swathi; Chenoweth, David M et al. (2015) Optogenetic control of organelle transport using a photocaged chemical inducer of dimerization. Curr Biol 25:R407-R408
Ayloo, Swathi; Holzbaur, Erika L F (2015) Reconstitution of microtubule-based motility using cell extracts. Methods Cell Biol 128:57-68

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