Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM049054-10
Application #
6694040
Study Section
Alcohol and Toxicology Subcommittee 4 (ALTX)
Program Officer
Okita, Richard T
Project Start
1994-04-01
Project End
2006-12-31
Budget Start
2004-01-01
Budget End
2004-12-31
Support Year
10
Fiscal Year
2004
Total Cost
$265,942
Indirect Cost
Name
University of Washington
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Hsu, Mei-Hui; Baer, Brian R; Rettie, Allan E et al. (2017) The Crystal Structure of Cytochrome P450 4B1 (CYP4B1) Monooxygenase Complexed with Octane Discloses Several Structural Adaptations for ?-Hydroxylation. J Biol Chem 292:5610-5621
Parkinson, Oliver T; Teitelbaum, Aaron M; Whittington, Dale et al. (2016) Species Differences in Microsomal Oxidation and Glucuronidation of 4-Ipomeanol: Relationship to Target Organ Toxicity. Drug Metab Dispos 44:1598-602
Schmidt, Eva M; Wiek, Constanze; Parkinson, Oliver T et al. (2015) Characterization of an Additional Splice Acceptor Site Introduced into CYP4B1 in Hominoidae during Evolution. PLoS One 10:e0137110
Wiek, Constanze; Schmidt, Eva M; Roellecke, Katharina et al. (2015) Identification of amino acid determinants in CYP4B1 for optimal catalytic processing of 4-ipomeanol. Biochem J 465:103-14
Lockhart, Catherine M; Nakano, Mariko; Rettie, Allan E et al. (2014) Generation and characterization of a murine model of Bietti crystalline dystrophy. Invest Ophthalmol Vis Sci 55:5572-81
Nakano, Mariko; Lockhart, Catherine M; Kelly, Edward J et al. (2014) Ocular cytochrome P450s and transporters: roles in disease and endobiotic and xenobiotic disposition. Drug Metab Rev 46:247-60
Edson, Katheryne Z; Rettie, Allan E (2013) CYP4 enzymes as potential drug targets: focus on enzyme multiplicity, inducers and inhibitors, and therapeutic modulation of 20-hydroxyeicosatetraenoic acid (20-HETE) synthase and fatty acid ?-hydroxylase activities. Curr Top Med Chem 13:1429-40
Parkinson, Oliver T; Liggitt, H Denny; Rettie, Allan E et al. (2013) Generation and characterization of a Cyp4b1 null mouse and the role of CYP4B1 in the activation and toxicity of Ipomeanol. Toxicol Sci 134:243-50
Nakano, Mariko; Kelly, Edward J; Wiek, Constanze et al. (2012) CYP4V2 in Bietti's crystalline dystrophy: ocular localization, metabolism of ?-3-polyunsaturated fatty acids, and functional deficit of the p.H331P variant. Mol Pharmacol 82:679-86
Parkinson, O T; Kelly, E J; Bezabih, E et al. (2012) Bioactivation of 4-Ipomeanol by a CYP4B enzyme in bovine lung and inhibition by HET0016. J Vet Pharmacol Ther 35:402-5

Showing the most recent 10 out of 13 publications