Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM049135-03
Application #
2186677
Study Section
Pharmacology A Study Section (PHRA)
Project Start
1994-04-01
Project End
1998-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Savas, Uzen; Machemer, Daniel E W; Hsu, Mei-Hui et al. (2009) Opposing roles of peroxisome proliferator-activated receptor alpha and growth hormone in the regulation of CYP4A11 expression in a transgenic mouse model. J Biol Chem 284:16541-52
Argikar, U A; Senekeo-Effenberger, K; Larson, E E et al. (2009) Studies on induction of lamotrigine metabolism in transgenic UGT1 mice. Xenobiotica :
Operana, Theresa N; Nguyen, Nghia; Chen, Shujuan et al. (2007) Human CYP1A1GFP expression in transgenic mice serves as a biomarker for environmental toxicant exposure. Toxicol Sci 95:98-107
Yueh, Mei-Fei; Tukey, Robert H (2007) Nrf2-Keap1 signaling pathway regulates human UGT1A1 expression in vitro and in transgenic UGT1 mice. J Biol Chem 282:8749-58
Senekeo-Effenberger, Kathy; Chen, Shujuan; Brace-Sinnokrak, Erin et al. (2007) Expression of the human UGT1 locus in transgenic mice by 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid (WY-14643) and implications on drug metabolism through peroxisome proliferator-activated receptor alpha activation. Drug Metab Dispos 35:419-27
Bonzo, Jessica A; Belanger, Alain; Tukey, Robert H (2007) The role of chrysin and the ah receptor in induction of the human UGT1A1 gene in vitro and in transgenic UGT1 mice. Hepatology 45:349-60
Operana, Theresa N; Tukey, Robert H (2007) Oligomerization of the UDP-glucuronosyltransferase 1A proteins: homo- and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation. J Biol Chem 282:4821-9
Chen, Shujuan; Beaton, Deirdre; Nguyen, Nghia et al. (2005) Tissue-specific, inducible, and hormonal control of the human UDP-glucuronosyltransferase-1 (UGT1) locus. J Biol Chem 280:37547-57
Yueh, Mei-Fei; Huang, Yue-Hua; Hiller, Anita et al. (2003) Involvement of the xenobiotic response element (XRE) in Ah receptor-mediated induction of human UDP-glucuronosyltransferase 1A1. J Biol Chem 278:15001-6
Tukey, Robert H; Strassburg, Christian P; Mackenzie, Peter I (2002) Pharmacogenomics of human UDP-glucuronosyltransferases and irinotecan toxicity. Mol Pharmacol 62:446-50

Showing the most recent 10 out of 29 publications