Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM049243-04
Application #
2186811
Study Section
Biochemistry Study Section (BIO)
Project Start
1993-05-01
Project End
1998-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Stanford University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305
Gleitsman, Kristin R; Sengupta, Raghuvir N; Herschlag, Daniel (2017) Slow molecular recognition by RNA. RNA 23:1745-1753
Sunden, Fanny; AlSadhan, Ishraq; Lyubimov, Artem et al. (2017) Differential catalytic promiscuity of the alkaline phosphatase superfamily bimetallo core reveals mechanistic features underlying enzyme evolution. J Biol Chem 292:20960-20974
Sunden, Fanny; AlSadhan, Ishraq; Lyubimov, Artem Y et al. (2016) Mechanistic and Evolutionary Insights from Comparative Enzymology of Phosphomonoesterases and Phosphodiesterases across the Alkaline Phosphatase Superfamily. J Am Chem Soc 138:14273-14287
Sengupta, Raghuvir N; Van Schie, Sabine N S; Giamba?u, George et al. (2016) An active site rearrangement within the Tetrahymena group I ribozyme releases nonproductive interactions and allows formation of catalytic interactions. RNA 22:32-48
Peck, Ariana; Sunden, Fanny; Andrews, Logan D et al. (2016) Tungstate as a Transition State Analog for Catalysis by Alkaline Phosphatase. J Mol Biol 428:2758-68
van Schie, Sabine N S; Sengupta, Raghuvir N; Herschlag, Daniel (2016) Differential Assembly of Catalytic Interactions within the Conserved Active Sites of Two Ribozymes. PLoS One 11:e0160457
Chen, Bob; Lim, Sungwon; Kannan, Arvind et al. (2016) High-throughput analysis and protein engineering using microcapillary arrays. Nat Chem Biol 12:76-81
Sunden, Fanny; Peck, Ariana; Salzman, Julia et al. (2015) Extensive site-directed mutagenesis reveals interconnected functional units in the alkaline phosphatase active site. Elife 4:
Gleitsman, Kristin R; Herschlag, Daniel H (2014) A kinetic and thermodynamic framework for the Azoarcus group I ribozyme reaction. RNA 20:1732-46
Shi, Xuesong; Bisaria, Namita; Benz-Moy, Tara L et al. (2014) Roles of long-range tertiary interactions in limiting dynamics of the Tetrahymena group I ribozyme. J Am Chem Soc 136:6643-8

Showing the most recent 10 out of 76 publications