Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
3R01GM049700-03S1
Application #
2593535
Study Section
Microbial Physiology and Genetics Subcommittee 2 (MBC)
Project Start
1994-07-01
Project End
2000-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
3
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
Georgetown University
Department
Biochemistry
Type
Schools of Dentistry
DUNS #
049515844
City
Washington
State
DC
Country
United States
Zip Code
20057

  Publications

Saxena, Rahul; Vasudevan, Sona; Patil, Digvijay et al. (2015) Nucleotide-Induced Conformational Changes in Escherichia coli DnaA Protein Are Required for Bacterial ORC to Pre-RC Conversion at the Chromosomal Origin. Int J Mol Sci 16:27897-911
Saxena, Rahul; Fingland, Nicholas; Patil, Digvijay et al. (2013) Crosstalk between DnaA protein, the initiator of Escherichia coli chromosomal replication, and acidic phospholipids present in bacterial membranes. Int J Mol Sci 14:8517-37
Fingland, Nicholas; Flatten, Ingvild; Downey, Christopher D et al. (2012) Depletion of acidic phospholipids influences chromosomal replication in Escherichia coli. Microbiologyopen 1:450-66
Saxena, Rahul; Rozgaja, Tania; Grimwade, Julia et al. (2011) Remodeling of nucleoprotein complexes is independent of the nucleotide state of a mutant AAA+ protein. J Biol Chem 286:33770-7
Downey, Christopher D; Crooke, Elliott; McHenry, Charles S (2011) Polymerase chaperoning and multiple ATPase sites enable the E. coli DNA polymerase III holoenzyme to rapidly form initiation complexes. J Mol Biol 412:340-53
Boeneman, Kelly; Fossum, Solveig; Yang, Yanhua et al. (2009) Escherichia coli DnaA forms helical structures along the longitudinal cell axis distinct from MreB filaments. Mol Microbiol 72:645-57
Fossum, Solveig; Crooke, Elliott; Skarstad, Kirsten (2007) Organization of sister origins and replisomes during multifork DNA replication in Escherichia coli. EMBO J 26:4514-22
Camara, Johanna E; Breier, Adam M; Brendler, Therese et al. (2005) Hda inactivation of DnaA is the predominant mechanism preventing hyperinitiation of Escherichia coli DNA replication. EMBO Rep 6:736-41
Li, Zhenya; Kitchen, Jennifer L; Boeneman, Kelly et al. (2005) Restoration of growth to acidic phospholipid-deficient cells by DnaA(L366K) is independent of its capacity for nucleotide binding and exchange and requires DnaA. J Biol Chem 280:9796-801
Camara, Johanna Eltz; Skarstad, Kirsten; Crooke, Elliott (2003) Controlled initiation of chromosomal replication in Escherichia coli requires functional Hda protein. J Bacteriol 185:3244-8

Showing the most recent 10 out of 12 publications