Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM049857-03
Application #
2187408
Study Section
Molecular and Cellular Biophysics Study Section (BBCA)
Project Start
1994-05-01
Project End
1997-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Fred Hutchinson Cancer Research Center
Department
Type
DUNS #
075524595
City
Seattle
State
WA
Country
United States
Zip Code
98109
Shen, Betty W; Lambert, Abigail; Walker, Bradley C et al. (2016) The Structural Basis of Asymmetry in DNA Binding and Cleavage as Exhibited by the I-SmaMI LAGLIDADG Meganuclease. J Mol Biol 428:206-220
Ho, Joanne M; Reynolds, Noah M; Rivera, Keith et al. (2016) Efficient Reassignment of a Frequent Serine Codon in Wild-Type Escherichia coli. ACS Synth Biol 5:163-71
Doyle, Lindsey; Hallinan, Jazmine; Bolduc, Jill et al. (2015) Rational design of ?-helical tandem repeat proteins with closed architectures. Nature 528:585-8
Takeuchi, Ryo; Choi, Michael; Stoddard, Barry L (2015) Engineering of customized meganucleases via in vitro compartmentalization and in cellulo optimization. Methods Mol Biol 1239:105-32
Mandell, Daniel J; Lajoie, Marc J; Mee, Michael T et al. (2015) Biocontainment of genetically modified organisms by synthetic protein design. Nature 518:55-60
Park, Keunwan; Shen, Betty W; Parmeggiani, Fabio et al. (2015) Control of repeat-protein curvature by computational protein design. Nat Struct Mol Biol 22:167-74
Procko, Erik; Berguig, Geoffrey Y; Shen, Betty W et al. (2014) A computationally designed inhibitor of an Epstein-Barr viral Bcl-2 protein induces apoptosis in infected cells. Cell 157:1644-1656
Takeuchi, Ryo; Choi, Michael; Stoddard, Barry L (2014) Redesign of extensive protein-DNA interfaces of meganucleases using iterative cycles of in vitro compartmentalization. Proc Natl Acad Sci U S A 111:4061-6
Stoddard, Barry L (2014) Homing endonucleases from mobile group I introns: discovery to genome engineering. Mob DNA 5:7
Zhao, Lei; Stoddard, Barry L (2014) Rapid determination of homing endonuclease DNA binding specificity profile. Methods Mol Biol 1123:127-34

Showing the most recent 10 out of 47 publications