Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM050403-03
Application #
2188227
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1994-01-01
Project End
1997-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Iowa
Department
Biochemistry
Type
Schools of Medicine
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Lang, Michael J; Strunk, Bethany S; Azad, Nadia et al. (2017) An intramolecular interaction within the lipid kinase Fab1 regulates cellular phosphatidylinositol 3,5-bisphosphate lipid levels. Mol Biol Cell 28:858-864
Jin, Natsuko; Jin, Yui; Weisman, Lois S (2017) Early protection to stress mediated by CDK-dependent PI3,5P2 signaling from the vacuole/lysosome. J Cell Biol 216:2075-2090
Hasegawa, Junya; Strunk, Bethany S; Weisman, Lois S (2017) PI5P and PI(3,5)P2: Minor, but Essential Phosphoinositides. Cell Struct Funct 42:49-60
Kim, Seong M; Roy, Saurabh G; Chen, Bin et al. (2016) Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways. J Clin Invest 126:4088-4102
Jin, Natsuko; Lang, Michael J; Weisman, Lois S (2016) Phosphatidylinositol 3,5-bisphosphate: regulation of cellular events in space and time. Biochem Soc Trans 44:177-84
Jin, Yui; Strunk, Bethany S; Weisman, Lois S (2015) Close encounters of the lysosome-peroxisome kind. Cell 161:197-8
McCartney, Amber J; Zolov, Sergey N; Kauffman, Emily J et al. (2014) Activity-dependent PI(3,5)P2 synthesis controls AMPA receptor trafficking during synaptic depression. Proc Natl Acad Sci U S A 111:E4896-905
Li, Sheena Claire; Diakov, Theodore T; Xu, Tao et al. (2014) The signaling lipid PI(3,5)P? stabilizes V?-V(o) sector interactions and activates the V-ATPase. Mol Biol Cell 25:1251-62
McCartney, Amber J; Zhang, Yanling; Weisman, Lois S (2014) Phosphatidylinositol 3,5-bisphosphate: low abundance, high significance. Bioessays 36:52-64
Jin, Natsuko; Mao, Kai; Jin, Yui et al. (2014) Roles for PI(3,5)P2 in nutrient sensing through TORC1. Mol Biol Cell 25:1171-85

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