|
Finer-Moore, Janet; Czudnochowski, Nadine; O'Connell 3rd, Joseph D et al. (2015) Crystal Structure of the Human tRNA m(1)A58 Methyltransferase-tRNA(3)(Lys) Complex: Refolding of Substrate tRNA Allows Access to the Methylation Target. J Mol Biol 427:3862-76
|
|
Lohse, Matthew B; Rosenberg, Oren S; Cox, Jeffery S et al. (2014) Structure of a new DNA-binding domain which regulates pathogenesis in a wide variety of fungi. Proc Natl Acad Sci U S A 111:10404-10
|
|
Czudnochowski, Nadine; Ashley, Gary W; Santi, Daniel V et al. (2014) The mechanism of pseudouridine synthases from a covalent complex with RNA, and alternate specificity for U2605 versus U2604 between close homologs. Nucleic Acids Res 42:2037-48
|
|
Tochowicz, Anna; Dalziel, Sean; Eidam, Oliv et al. (2013) Development and binding mode assessment of N-[4-[2-propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-3H-cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-l-?-glutamyl-D-glutamic acid (BGC 945), a novel thymidylate synthase inhibitor that targets tumor J Med Chem 56:5446-55
|
|
Czudnochowski, Nadine; Wang, Amy Liya; Finer-Moore, Janet et al. (2013) In human pseudouridine synthase 1 (hPus1), a C-terminal helical insert blocks tRNA from binding in the same orientation as in the Pus1 bacterial homologue TruA, consistent with their different target selectivities. J Mol Biol 425:3875-87
|
|
Wang, Zhen; Sapienza, Paul J; Abeysinghe, Thelma et al. (2013) Mg2+ binds to the surface of thymidylate synthase and affects hydride transfer at the interior active site. J Am Chem Soc 135:7583-92
|
|
Wang, Zhen; Abeysinghe, Thelma; Finer-Moore, Janet S et al. (2012) A remote mutation affects the hydride transfer by disrupting concerted protein motions in thymidylate synthase. J Am Chem Soc 134:17722-30
|
|
Rosenberg, Oren S; Dovey, Cole; Tempesta, Michael et al. (2011) EspR, a key regulator of Mycobacterium tuberculosis virulence, adopts a unique dimeric structure among helix-turn-helix proteins. Proc Natl Acad Sci U S A 108:13450-5
|
|
Alian, Akram; DeGiovanni, Andrew; Griner, Sarah L et al. (2009) Crystal structure of an RluF-RNA complex: a base-pair rearrangement is the key to selectivity of RluF for U2604 of the ribosome. J Mol Biol 388:785-800
|
|
Alian, Akram; Lee, Tom T; Griner, Sarah L et al. (2008) Structure of a TrmA-RNA complex: A consensus RNA fold contributes to substrate selectivity and catalysis in m5U methyltransferases. Proc Natl Acad Sci U S A 105:6876-81
|
Showing the most recent 10 out of 31 publications
