Regulation of Gene Expression by DNA Binding Ligands

Dervan, Peter B.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of General Medical Sciences (NIGMS)
• Type: Research Project (R01)
• Project #: 3R01GM051747-14S1
• Application #: 6801691
• Study Section: Bio-Organic and Natural Products Chemistry Study Section (BNP)
• Program Officer: Lewis, Catherine D
• Project Start: 1989-07-01
• Project End: 2007-03-31
• Budget Start: 2003-04-07
• Budget End: 2004-03-31
• Support Year: 14
• Fiscal Year: 2003
• Total Cost: $12,420

Institution

• Name: California Institute of Technology
• Type: Schools of Engineering
• DUNS #: 009584210
• City: Pasadena
• State: CA
• Country: United States
• Zip Code: 91125

Publications

Mysore, Veena S; Szablowski, Jerzy; Dervan, Peter B et al. (2016) A DNA-binding Molecule Targeting the Adaptive Hypoxic Response in Multiple Myeloma Has Potent Antitumor Activity. Mol Cancer Res 14:253-66

Szablowski, Jerzy O; Raskatov, Jevgenij A; Dervan, Peter B (2016) An HRE-Binding Py-Im Polyamide Impairs Hypoxic Signaling in Tumors. Mol Cancer Ther 15:608-17

Kang, JeenJoo S; Dervan, Peter B (2015) A sequence-specific DNA binding small molecule triggers the release of immunogenic signals and phagocytosis in a model of B-cell lymphoma. Q Rev Biophys 48:453-64

Kang, JeenJoo S; Meier, Jordan L; Dervan, Peter B (2014) Design of sequence-specific DNA binding molecules for DNA methyltransferase inhibition. J Am Chem Soc 136:3687-94

Raskatov, Jevgenij A; Szablowski, Jerzy O; Dervan, Peter B (2014) Tumor xenograft uptake of a pyrrole-imidazole (Py-Im) polyamide varies as a function of cell line grafted. J Med Chem 57:8471-6

Martínez, Thomas F; Phillips, John W; Karanja, Kenneth K et al. (2014) Replication stress by Py-Im polyamides induces a non-canonical ATR-dependent checkpoint response. Nucleic Acids Res 42:11546-59

Raskatov, Jevgenij A; Puckett, James W; Dervan, Peter B (2014) A C-14 labeled Py-Im polyamide localizes to a subcutaneous prostate cancer tumor. Bioorg Med Chem 22:4371-5

Nickols, Nicholas G; Szablowski, Jerzy O; Hargrove, Amanda E et al. (2013) Activity of a Py-Im polyamide targeted to the estrogen response element. Mol Cancer Ther 12:675-84

Edwards, Jonathan S; Betts, Laurie; Frazier, Monica L et al. (2013) Molecular basis of antibiotic multiresistance transfer in Staphylococcus aureus. Proc Natl Acad Sci U S A 110:2804-9

Hargrove, Amanda E; Raskatov, Jevgenij A; Meier, Jordan L et al. (2012) Characterization and solubilization of pyrrole-imidazole polyamide aggregates. J Med Chem 55:5425-32