Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
1R01GM052419-01A1
Application #
2191435
Study Section
Physical Biochemistry Study Section (PB)
Project Start
1996-04-01
Project End
2000-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Texas Health Science Center San Antonio
Department
Biochemistry
Type
Schools of Medicine
DUNS #
800772162
City
San Antonio
State
TX
Country
United States
Zip Code
78229
Kang, Soosung; Li, Huiying; Tang, Wei et al. (2015) 2-Aminopyridines with a Truncated Side Chain To Improve Human Neuronal Nitric Oxide Synthase Inhibitory Potency and Selectivity. J Med Chem 58:5548-60
Astashkin, Andrei V; Chen, Li; Elmore, Bradley O et al. (2015) Probing the Hydrogen Bonding of the Ferrous-NO Heme Center of nNOS by Pulsed Electron Paramagnetic Resonance. J Phys Chem A 119:6641-9
Jing, Qing; Li, Huiying; Roman, Linda J et al. (2014) Combination of chiral linkers with thiophenecarboximidamide heads to improve the selectivity of inhibitors of neuronal nitric oxide synthase. Bioorg Med Chem Lett 24:4504-4510
Cinelli, Maris A; Li, Huiying; Chreifi, Georges et al. (2014) Simplified 2-aminoquinoline-based scaffold for potent and selective neuronal nitric oxide synthase inhibition. J Med Chem 57:1513-30
Kang, Soosung; Tang, Wei; Li, Huiying et al. (2014) Nitric oxide synthase inhibitors that interact with both heme propionate and tetrahydrobiopterin show high isoform selectivity. J Med Chem 57:4382-96
Volkmann, Niels; Martásek, Pavel; Roman, Linda J et al. (2014) Holoenzyme structures of endothelial nitric oxide synthase - an allosteric role for calmodulin in pivoting the FMN domain for electron transfer. J Struct Biol 188:46-54
Huang, He; Li, Huiying; Yang, Sun et al. (2014) Potent and selective double-headed thiophene-2-carboximidamide inhibitors of neuronal nitric oxide synthase for the treatment of melanoma. J Med Chem 57:686-700
Trane, Andy E; Pavlov, Dmitri; Sharma, Arpeeta et al. (2014) Deciphering the binding of caveolin-1 to client protein endothelial nitric-oxide synthase (eNOS): scaffolding subdomain identification, interaction modeling, and biological significance. J Biol Chem 289:13273-83
Jansen Labby, Kristin; Li, Huiying; Roman, Linda J et al. (2013) Methylated N(?)-hydroxy-L-arginine analogues as mechanistic probes for the second step of the nitric oxide synthase-catalyzed reaction. Biochemistry 52:3062-73
Jing, Qing; Li, Huiying; Chreifi, Georges et al. (2013) Chiral linkers to improve selectivity of double-headed neuronal nitric oxide synthase inhibitors. Bioorg Med Chem Lett 23:5674-9

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