Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM052522-02
Application #
2191581
Study Section
Microbial Physiology and Genetics Subcommittee 2 (MBC)
Project Start
1995-09-30
Project End
2000-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Texas Health Science Center San Antonio
Department
Biochemistry
Type
Schools of Medicine
DUNS #
800772162
City
San Antonio
State
TX
Country
United States
Zip Code
78229
Liu, Yu; Holmstrom, Erik; Zhang, Jinwei et al. (2015) Synthesis and applications of RNAs with position-selective labelling and mosaic composition. Nature 522:368-72
Velazquez, Gilberto; Sousa, Rui; Brieba, Luis G (2015) The thumb subdomain of yeast mitochondrial RNA polymerase is involved in processivity, transcript fidelity and mitochondrial transcription factor binding. RNA Biol 12:514-24
Drakulic, Srdja; Wang, Liping; Cuéllar, Jorge et al. (2014) Yeast mitochondrial RNAP conformational changes are regulated by interactions with the mitochondrial transcription factor. Nucleic Acids Res 42:11246-60
Velazquez, Gilberto; Guo, Qing; Wang, Liping et al. (2012) Conservation of promoter melting mechanisms in divergent regions of the single-subunit RNA polymerases. Biochemistry 51:3901-10
Sousa, Rui (2012) A dancer caught midstep: the structure of ATP-bound Hsp70. Mol Cell 48:821-3
Li, Yifeng; Sousa, Rui (2012) Novel system for in vivo biotinylation and its application to crab antimicrobial protein scygonadin. Biotechnol Lett 34:1629-35
Li, Yifeng; Sousa, Rui (2012) Expression and purification of E. coli BirA biotin ligase for in vitro biotinylation. Protein Expr Purif 82:162-7
Sousa, Rui (2009) Comment on ""Xeno's paradox"". EMBO Rep 10:800
Woo, Hyung-June; Jiang, Jianwen; Lafer, Eileen M et al. (2009) ATP-induced conformational changes in Hsp70: molecular dynamics and experimental validation of an in silico predicted conformation. Biochemistry 48:11470-7
Nayak, Dhananjaya; Guo, Qing; Sousa, Rui (2009) A promoter recognition mechanism common to yeast mitochondrial and phage t7 RNA polymerases. J Biol Chem 284:13641-7

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