Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM052594-02
Application #
2191687
Study Section
Biochemistry Study Section (BIO)
Project Start
1995-08-02
Project End
1999-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Illinois Urbana-Champaign
Department
Biochemistry
Type
Schools of Arts and Sciences
DUNS #
041544081
City
Champaign
State
IL
Country
United States
Zip Code
61820
Gerlt, John A; Babbitt, Patricia C (2009) Enzyme (re)design: lessons from natural evolution and computation. Curr Opin Chem Biol 13:10-8
Rakus, John F; Fedorov, Alexander A; Fedorov, Elena V et al. (2008) Evolution of enzymatic activities in the enolase superfamily: L-rhamnonate dehydratase. Biochemistry 47:9944-54
Vick, Jacob E; Gerlt, John A (2007) Evolutionary potential of (beta/alpha)8-barrels: stepwise evolution of a ""new"" reaction in the enolase superfamily. Biochemistry 46:14589-97
Rakus, John F; Fedorov, Alexander A; Fedorov, Elena V et al. (2007) Evolution of enzymatic activities in the enolase superfamily: D-Mannonate dehydratase from Novosphingobium aromaticivorans. Biochemistry 46:12896-908
Glasner, Margaret E; Gerlt, John A; Babbitt, Patricia C (2007) Mechanisms of protein evolution and their application to protein engineering. Adv Enzymol Relat Areas Mol Biol 75:193-239, xii-xiii
Glasner, Margaret E; Gerlt, John A; Babbitt, Patricia C (2006) Evolution of enzyme superfamilies. Curr Opin Chem Biol 10:492-7
Brown, Shoshana D; Gerlt, John A; Seffernick, Jennifer L et al. (2006) A gold standard set of mechanistically diverse enzyme superfamilies. Genome Biol 7:R8
Yew, Wen Shan; Fedorov, Alexander A; Fedorov, Elena V et al. (2006) Evolution of enzymatic activities in the enolase superfamily: D-tartrate dehydratase from Bradyrhizobium japonicum. Biochemistry 45:14598-608
Yew, Wen Shan; Fedorov, Alexander A; Fedorov, Elena V et al. (2006) Evolution of enzymatic activities in the enolase superfamily: L-fuconate dehydratase from Xanthomonas campestris. Biochemistry 45:14582-97
Sakai, Ayano; Xiang, Dao Feng; Xu, Chengfu et al. (2006) Evolution of enzymatic activities in the enolase superfamily: N-succinylamino acid racemase and a new pathway for the irreversible conversion of D- to L-amino acids. Biochemistry 45:4455-62

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