Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM052890-02
Application #
2192086
Study Section
Pathobiochemistry Study Section (PBC)
Project Start
1995-08-01
Project End
1999-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Cornell University
Department
Pathology
Type
Schools of Veterinary Medicine
DUNS #
City
Ithaca
State
NY
Country
United States
Zip Code
14850
Liu, Fei; Fang, Fang; Yuan, Hebao et al. (2013) Suppression of autophagy by FIP200 deletion leads to osteopenia in mice through the inhibition of osteoblast terminal differentiation. J Bone Miner Res 28:2414-30
Guan, Jun-Lin; Simon, Anna Katharina; Prescott, Mark et al. (2013) Autophagy in stem cells. Autophagy 9:830-49
Kim, Myungjin; Park, Hae Li; Park, Hwan-Woo et al. (2013) Drosophila Fip200 is an essential regulator of autophagy that attenuates both growth and aging. Autophagy 9:1201-13
Wang, Chenran; Liang, Chun-Chi; Bian, Z Christine et al. (2013) FIP200 is required for maintenance and differentiation of postnatal neural stem cells. Nat Neurosci 16:532-42
Fan, Huaping; Guan, Jun-Lin (2011) Compensatory function of Pyk2 protein in the promotion of focal adhesion kinase (FAK)-null mammary cancer stem cell tumorigenicity and metastatic activity. J Biol Chem 286:18573-82
Peng, Xu; Guan, Jun-Lin (2011) Focal adhesion kinase: from in vitro studies to functional analyses in vivo. Curr Protein Pept Sci 12:52-67
Bae, Heekyong; Guan, Jun-Lin (2011) Suppression of autophagy by FIP200 deletion impairs DNA damage repair and increases cell death upon treatments with anticancer agents. Mol Cancer Res 9:1232-41
Liang, Chun-Chi; Wang, Chenran; Peng, Xu et al. (2010) Neural-specific deletion of FIP200 leads to cerebellar degeneration caused by increased neuronal death and axon degeneration. J Biol Chem 285:3499-509
Liu, Fei; Lee, Jae Y; Wei, Huijun et al. (2010) FIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells. Blood 116:4806-14
Guan, Jun-Lin (2010) Integrin signaling through FAK in the regulation of mammary stem cells and breast cancer. IUBMB Life 62:268-76

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