Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
7R01GM053209-02
Application #
2192521
Study Section
Special Emphasis Panel (ZRG7-SB (01))
Project Start
1995-07-01
Project End
1999-06-30
Budget Start
1996-01-01
Budget End
1996-06-30
Support Year
2
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Rhode Island Hospital (Providence, RI)
Department
Type
DUNS #
161202122
City
Providence
State
RI
Country
United States
Zip Code
02903
Wang, Fei; Huang, Xin; Chung, Chun-Shiang et al. (2016) Contribution of programmed cell death receptor (PD)-1 to Kupffer cell dysfunction in murine polymicrobial sepsis. Am J Physiol Gastrointest Liver Physiol 311:G237-45
Cheng, Tingting; Bai, Jianwen; Chung, Chun-Shiang et al. (2016) Enhanced Innate Inflammation Induced by Anti-BTLA Antibody in Dual Insult Model of Hemorrhagic Shock/Sepsis. Shock 45:40-9
Hutchins, Noelle A; Chung, Chun-Shiang; Borgerding, Joshua N et al. (2013) Kupffer cells protect liver sinusoidal endothelial cells from Fas-dependent apoptosis in sepsis by down-regulating gp130. Am J Pathol 182:742-54
Heffernan, Daithi S; Monaghan, Sean F; Thakkar, Rajan K et al. (2013) Inflammatory mechanisms in sepsis: elevated invariant natural killer T-cell numbers in mouse and their modulatory effect on macrophage function. Shock 40:122-8
Shubin, Nicholas J; Monaghan, Sean F; Heffernan, Daithi S et al. (2013) B and T lymphocyte attenuator expression on CD4+ T-cells associates with sepsis and subsequent infections in ICU patients. Crit Care 17:R276
Hutchins, Noelle A; Wang, Fei; Wang, Yvonne et al. (2013) Kupffer cells potentiate liver sinusoidal endothelial cell injury in sepsis by ligating programmed cell death ligand-1. J Leukoc Biol 94:963-70
Shubin, Nicholas J; Chung, Chun S; Heffernan, Daithi S et al. (2012) BTLA expression contributes to septic morbidity and mortality by inducing innate inflammatory cell dysfunction. J Leukoc Biol 92:593-603
Shubin, Nicholas J; Monaghan, Sean F; Ayala, Alfred (2011) Anti-inflammatory mechanisms of sepsis. Contrib Microbiol 17:108-24
McNeal, Sam I; LeGolvan, Mark P; Chung, Chun-Shiang et al. (2011) The dual functions of receptor interacting protein 1 in fas-induced hepatocyte death during sepsis. Shock 35:499-505
Guignant, Caroline; Lepape, Alain; Huang, Xin et al. (2011) Programmed death-1 levels correlate with increased mortality, nosocomial infection and immune dysfunctions in septic shock patients. Crit Care 15:R99

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