Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
1R01GM053763-01
Application #
2193171
Study Section
Biochemistry Study Section (BIO)
Project Start
1996-03-01
Project End
1999-02-28
Budget Start
1996-03-01
Budget End
1997-02-28
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California Santa Barbara
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
City
Santa Barbara
State
CA
Country
United States
Zip Code
93106
Menezes, Sheena; Gaston, Kirk W; Krivos, Kady L et al. (2011) Formation of m2G6 in Methanocaldococcus jannaschii tRNA catalyzed by the novel methyltransferase Trm14. Nucleic Acids Res 39:7641-55
Hancock, Stephen P; Hiller, David A; Perona, John J et al. (2011) The energetic contribution of induced electrostatic asymmetry to DNA bending by a site-specific protein. J Mol Biol 406:285-312
Hou, Ya-Ming; Perona, John J (2010) Stereochemical mechanisms of tRNA methyltransferases. FEBS Lett 584:278-86
Christian, Thomas; Lahoud, Georges; Liu, Cuiping et al. (2010) Mechanism of N-methylation by the tRNA m1G37 methyltransferase Trm5. RNA 16:2484-92
Estabrook, R August; Nguyen, Trung T; Fera, Nickolas et al. (2009) Coupling sequence-specific recognition to DNA modification. J Biol Chem 284:22690-6
Coffin, Stephanie R; Reich, Norbert O (2008) Modulation of Escherichia coli DNA methyltransferase activity by biologically derived GATC-flanking sequences. J Biol Chem 283:20106-16
Shieh, Fa-Kuen; Reich, Norbert O (2007) AdoMet-dependent methyl-transfer: Glu119 is essential for DNA C5-cytosine methyltransferase M.HhaI. J Mol Biol 373:1157-68
Youngblood, Ben; Shieh, Fa-Kuen; Buller, Fabian et al. (2007) S-adenosyl-L-methionine-dependent methyl transfer: observable precatalytic intermediates during DNA cytosine methylation. Biochemistry 46:8766-75
Hiller, David A; Perona, John J (2006) Positively charged C-terminal subdomains of EcoRV endonuclease: contributions to DNA binding, bending, and cleavage. Biochemistry 45:11453-63
Youngblood, Ben; Buller, Fabian; Reich, Norbert O (2006) Determinants of sequence-specific DNA methylation: target recognition and catalysis are coupled in M.HhaI. Biochemistry 45:15563-72

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