Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
1R01GM053819-01
Application #
2193231
Study Section
Physiological Chemistry Study Section (PC)
Project Start
1996-03-01
Project End
2000-02-29
Budget Start
1996-03-01
Budget End
1997-02-28
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Wright State University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
City
Dayton
State
OH
Country
United States
Zip Code
45435
Gao, Yanzhe; Yao, Jianhong; Poudel, Sumeet et al. (2014) Protein phosphatase 2A and Cdc7 kinase regulate the DNA unwinding element-binding protein in replication initiation. J Biol Chem 289:35987-6000
Chen, Xiaomi; Liu, Guoqi; Leffak, Michael (2013) Activation of a human chromosomal replication origin by protein tethering. Nucleic Acids Res 41:6460-74
Liu, Guoqi; Chen, Xiaomi; Leffak, Michael (2013) Oligodeoxynucleotide binding to (CTG) ýý (CAG) microsatellite repeats inhibits replication fork stalling, hairpin formation, and genome instability. Mol Cell Biol 33:571-81
Liu, Guoqi; Chen, Xiaomi; Gao, Yanzhe et al. (2012) Altered replication in human cells promotes DMPK (CTG)(n) · (CAG)(n) repeat instability. Mol Cell Biol 32:1618-32
Liu, Guoqi; Myers, Sheré; Chen, Xiaomi et al. (2012) Replication fork stalling and checkpoint activation by a PKD1 locus mirror repeat polypurine-polypyrimidine (Pu-Py) tract. J Biol Chem 287:33412-23
Chowdhury, A; Liu, G; Kemp, M et al. (2010) The DNA unwinding element binding protein DUE-B interacts with Cdc45 in preinitiation complex formation. Mol Cell Biol 30:1495-507
Liu, Guoqi; Chen, Xiaomi; Bissler, John J et al. (2010) Replication-dependent instability at (CTG) x (CAG) repeat hairpins in human cells. Nat Chem Biol 6:652-9
Kemp, Michael; Bae, Brian; Yu, John Paul et al. (2007) Structure and function of the c-myc DNA-unwinding element-binding protein DUE-B. J Biol Chem 282:10441-8
Liu, Guoqi; Bissler, John J; Sinden, Richard R et al. (2007) Unstable spinocerebellar ataxia type 10 (ATTCT*(AGAAT) repeats are associated with aberrant replication at the ATX10 locus and replication origin-dependent expansion at an ectopic site in human cells. Mol Cell Biol 27:7828-38