Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM054346-07
Application #
6402652
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Program Officer
Ikeda, Richard A
Project Start
1996-07-01
Project End
2003-06-30
Budget Start
2001-07-01
Budget End
2002-06-30
Support Year
7
Fiscal Year
2001
Total Cost
$304,288
Indirect Cost

  Institution

Name
University of Texas Austin
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
City
Austin
State
TX
Country
United States
Zip Code
78712

  Publications

Lin, Chia-I; McCarty, Reid M; Liu, Hung-wen (2013) The biosynthesis of nitrogen-, sulfur-, and high-carbon chain-containing sugars. Chem Soc Rev 42:4377-407
Sun, He G; Ruszczycky, Mark W; Chang, Wei-Chen et al. (2012) Nucleophilic participation of reduced flavin coenzyme in mechanism of UDP-galactopyranose mutase. J Biol Chem 287:4602-8
Choi, Sei-hyun; Mansoorabadi, Steven O; Liu, Yung-nan et al. (2012) Analysis of UDP-D-apiose/UDP-D-xylose synthase-catalyzed conversion of UDP-D-apiose phosphonate to UDP-D-xylose phosphonate: implications for a retroaldol-aldol mechanism. J Am Chem Soc 134:13946-9
Choi, Sei-hyun; Ruszczycky, Mark W; Zhang, Hua et al. (2011) A fluoro analogue of UDP-*-D-glucuronic acid is an inhibitor of UDP-*-D-apiose/UDP-*-D-xylose synthase. Chem Commun (Camb) 47:10130-2
Ruszczycky, Mark W; Choi, Sei-hyun; Mansoorabadi, Steven O et al. (2011) Mechanistic studies of the radical S-adenosyl-L-methionine enzyme DesII: EPR characterization of a radical intermediate generated during its catalyzed dehydrogenation of TDP-D-quinovose. J Am Chem Soc 133:7292-5
Romo, Anthony J; Liu, Hung-wen (2011) Mechanisms and structures of vitamin B(6)-dependent enzymes involved in deoxy sugar biosynthesis. Biochim Biophys Acta 1814:1534-47
Sasaki, Eita; Liu, Hung-Wen (2010) Mechanistic studies of the biosynthesis of 2-thiosugar: evidence for the formation of an enzyme-bound 2-ketohexose intermediate in BexX-catalyzed reaction. J Am Chem Soc 132:15544-6
Sasaki, Eita; Ogasawara, Yasushi; Liu, Hung-Wen (2010) A biosynthetic pathway for BE-7585A, a 2-thiosugar-containing angucycline-type natural product. J Am Chem Soc 132:7405-17
Borisova, Svetlana A; Liu, Hung-Wen (2010) Characterization of glycosyltransferase DesVII and its auxiliary partner protein DesVIII in the methymycin/picromycin biosynthetic pathway. Biochemistry 49:8071-84
Borisova, Svetlana A; Guppi, Sanjeeva R; Kim, Hak Joong et al. (2010) A de novo approach to the synthesis of glycosylated methymycin analogues with structural and stereochemical diversity. Org Lett 12:5150-3

Showing the most recent 10 out of 50 publications