Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
3R01GM054778-01A1S1
Application #
2678507
Study Section
Microbial Physiology and Genetics Subcommittee 2 (MBC)
Project Start
1997-08-01
Project End
2001-07-31
Budget Start
1997-08-01
Budget End
1998-07-31
Support Year
1
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Colorado at Boulder
Department
Biochemistry
Type
Schools of Arts and Sciences
DUNS #
City
Boulder
State
CO
Country
United States
Zip Code
80309
Eustice, Moriah; Pillus, Lorraine (2014) Unexpected function of the glucanosyltransferase Gas1 in the DNA damage response linked to histone H3 acetyltransferases in Saccharomyces cerevisiae. Genetics 196:1029-39
McCormick, Mark A; Mason, Amanda G; Guyenet, Stephan J et al. (2014) The SAGA histone deubiquitinase module controls yeast replicative lifespan via Sir2 interaction. Cell Rep 8:477-86
Garza, Renee; Pillus, Lorraine (2013) STUbLs in chromatin and genome stability. Biopolymers 99:146-54
Freeman-Cook, Lisa L; Gomez, Eliana B; Spedale, Erik J et al. (2005) Conserved locus-specific silencing functions of Schizosaccharomyces pombe sir2+. Genetics 169:1243-60
Parsons, Xuejun Huang; Garcia, Sandra N; Pillus, Lorraine et al. (2003) Histone deacetylation by Sir2 generates a transcriptionally repressed nucleoprotein complex. Proc Natl Acad Sci U S A 100:1609-14
Landry, J; Sutton, A; Tafrov, S T et al. (2000) The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases. Proc Natl Acad Sci U S A 97:5807-11
Smith, J S; Brachmann, C B; Pillus, L et al. (1998) Distribution of a limited Sir2 protein pool regulates the strength of yeast rDNA silencing and is modulated by Sir4p. Genetics 149:1205-19