Abstract

Candida albicans is one of the most frequently isolated fungal pathogens of humans. It can undergo reversible morphogenetic transitions among budding yeast, pseudohyphal, and hyphal growth forms. Its unique ability to switch from yeast to hyphal growth in response to various environmental signals not only is inherent to its pathogenicity, but also provides an excellent paradigm to understand how signaling pathways coordinate growth and development. The objectives of this research are to understand how hyphal signaling pathways integrate external signals with temporal and spatial cues to generate linear hyphal filaments. There are five specific aims: (1) Activation of hyphal signaling during the initial response to hyphal inducing conditions. (2) Regulation of hyphal signaling by cell cycle. (3) Regulation of hyphal signaling by cell polarity. (4) Identification of targets of hyphal signaling that control cell polarity. (5) Apical cell-specific localization and linear cell division.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM055155-13
Application #
7578335
Study Section
Pathogenic Eukaryotes Study Section (PTHE)
Project Start
1997-01-01
Project End
2010-09-26
Budget Start
2009-03-01
Budget End
2010-09-26
Support Year
13
Fiscal Year
2009
Total Cost
$298,188
Indirect Cost

  Institution

Name
University of California Irvine
Department
Biochemistry
Type
Schools of Medicine
DUNS #
046705849
City
Irvine
State
CA
Country
United States
Zip Code
92697

  Publications

Mood, Aaron D; Premachandra, Ilandari Dewage Udara Anulal; Hiew, Stanley et al. (2017) Potent Antifungal Synergy of Phthalazinone and Isoquinolones with Azoles Against Candida albicans. ACS Med Chem Lett 8:168-173
Su, Chang; Lu, Yang; Liu, Haoping (2016) N-acetylglucosamine sensing by a GCN5-related N-acetyltransferase induces transcription via chromatin histone acetylation in fungi. Nat Commun 7:12916
Guan, Zhiyun; Liu, Haoping (2015) Overlapping Functions between SWR1 Deletion and H3K56 Acetylation in Candida albicans. Eukaryot Cell 14:578-87
Yan, Minghui; Nie, Xinyi; Wang, Huafeng et al. (2015) SUMOylation of Wor1 by a novel SUMO E3 ligase controls cell fate in Candida albicans. Mol Microbiol 98:69-89
Guan, Zhiyun; Liu, Haoping (2015) The WOR1 5' untranslated region regulates white-opaque switching in Candida albicans by reducing translational efficiency. Mol Microbiol 97:125-38
Lane, Shelley; Di Lena, Pietro; Tormanen, Kati et al. (2015) Function and Regulation of Cph2 in Candida albicans. Eukaryot Cell 14:1114-26
Lu, Yang; Su, Chang; Liu, Haoping (2014) Candida albicans hyphal initiation and elongation. Trends Microbiol 22:707-14
Stevenson, John S; Liu, Haoping (2013) Nucleosome assembly factors CAF-1 and HIR modulate epigenetic switching frequencies in an H3K56 acetylation-associated manner in Candida albicans. Eukaryot Cell 12:591-603
Lu, Yang; Su, Chang; Solis, Norma V et al. (2013) Synergistic regulation of hyphal elongation by hypoxia, CO(2), and nutrient conditions controls the virulence of Candida albicans. Cell Host Microbe 14:499-509
Su, Chang; Lu, Yang; Liu, Haoping (2013) Reduced TOR signaling sustains hyphal development in Candida albicans by lowering Hog1 basal activity. Mol Biol Cell 24:385-97

Showing the most recent 10 out of 29 publications