Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
1R01GM055479-01
Application #
2194312
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1996-08-01
Project End
2001-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Washington University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Cunningham, Trevor J; Tabacchi, Mary; Eliane, Jean-Pierre et al. (2017) Randomized trial of calcipotriol combined with 5-fluorouracil for skin cancer precursor immunotherapy. J Clin Invest 127:106-116
Turkoz, Mustafa; Townsend, R Reid; Kopan, Raphael (2016) The Notch Intracellular Domain Has an RBPj-Independent Role during Mouse Hair Follicular Development. J Invest Dermatol 136:1106-1115
Kopan, Raphael (2016) The Unaimed Arrow Never Misses. Curr Top Dev Biol 116:547-50
Thomas, Jane J; Abed, Mona; Heuberger, Julian et al. (2016) RNF4-Dependent Oncogene Activation by Protein Stabilization. Cell Rep 16:3388-3400
Liu, Zhenyi; Brunskill, Eric; Boyle, Scott et al. (2015) Second-generation Notch1 activity-trap mouse line (N1IP::CreHI) provides a more comprehensive map of cells experiencing Notch1 activity. Development 142:1193-202
Ilagan, Ma Xenia G; Kopan, Raphael (2014) Monitoring Notch activation in cultured mammalian cells: transcriptional reporter assays. Methods Mol Biol 1187:143-54
Kopan, Raphael; Chen, Shuang; Liu, Zhenyi (2014) Alagille, Notch, and robustness: why duplicating systems does not ensure redundancy. Pediatr Nephrol 29:651-7
Liu, Zhenyi; Chen, Shuang; Boyle, Scott et al. (2013) The extracellular domain of Notch2 increases its cell-surface abundance and ligand responsiveness during kidney development. Dev Cell 25:585-98
Satpathy, Ansuman T; BriseƱo, Carlos G; Lee, Jacob S et al. (2013) Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens. Nat Immunol 14:937-48
Liu, Zhiyong; Liu, Zhenyi; Walters, Bradley J et al. (2013) In vivo visualization of Notch1 proteolysis reveals the heterogeneity of Notch1 signaling activity in the mouse cochlea. PLoS One 8:e64903

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