The PI will continue to study molecular controls of apoptosis in Drosophila. The reaper gene, which was shown by the PI to have a central role in initiation of apoptosis, will be used in a dosage sensitive manner to conduct genetic screens for other cell death genes in Drosophila. In preliminary work, chromosomal deletions and point mutations have been recognized which enhance or suppress reaper derived cell death. In the proposed work: (1) Such screens will be extended in an effort to collect effector genes. These should encode functions responding to reaper expression and responsible for providing specific elements of the cell death machinery. (2) Effector genes will be cloned and characterized at the molecular level. (3) Phenotypes of loss of function mutations at effector loci will be examined independent of modulation of reaper to better understand the role of each gene in control of cell death.
| Arya, R; Sarkissian, T; Tan, Y et al. (2015) Neural stem cell progeny regulate stem cell death in a Notch and Hox dependent manner. Cell Death Differ 22:1378-87 |
| Arya, Richa; White, Kristin (2015) Cell death in development: Signaling pathways and core mechanisms. Semin Cell Dev Biol 39:12-9 |
| Sarkissian, Tatevik; Timmons, Allison; Arya, Richa et al. (2014) Detecting apoptosis in Drosophila tissues and cells. Methods 68:89-96 |
| Abdelwahid, Eltyeb; Rolland, Stephane; Teng, Xinchen et al. (2011) Mitochondrial involvement in cell death of non-mammalian eukaryotes. Biochim Biophys Acta 1813:597-607 |
| Thomenius, M; Freel, C D; Horn, S et al. (2011) Mitochondrial fusion is regulated by Reaper to modulate Drosophila programmed cell death. Cell Death Differ 18:1640-50 |
| Tan, Ying; Yamada-Mabuchi, Megumu; Arya, Richa et al. (2011) Coordinated expression of cell death genes regulates neuroblast apoptosis. Development 138:2197-206 |
| Wu, Julie N; Nguyen, Nguyen; Aghazarian, Maral et al. (2010) grim promotes programmed cell death of Drosophila microchaete glial cells. Mech Dev 127:407-17 |
| Krieser, Ronald J; White, Kristin (2009) Inside an enigma: do mitochondria contribute to cell death in Drosophila? Apoptosis 14:961-8 |
| Moon, Nam-Sung; Di Stefano, Luisa; Morris, Erick J et al. (2008) E2F and p53 induce apoptosis independently during Drosophila development but intersect in the context of DNA damage. PLoS Genet 4:e1000153 |
| Tseng, Ai-Sun Kelly; Tapon, Nicolas; Kanda, Hiroshi et al. (2007) Capicua regulates cell proliferation downstream of the receptor tyrosine kinase/ras signaling pathway. Curr Biol 17:728-33 |
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