Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM056528-17
Application #
6687796
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Program Officer
Jones, Warren
Project Start
1987-04-01
Project End
2006-11-30
Budget Start
2003-12-01
Budget End
2004-11-30
Support Year
17
Fiscal Year
2004
Total Cost
$412,940
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
781613492
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Mills, Jeremy H; Lee, Hyun Soo; Liu, Chang C et al. (2009) A genetically encoded direct sensor of antibody-antigen interactions. Chembiochem 10:2162-4
Graziano, James J; Liu, Wenshe; Perera, Roshan et al. (2008) Selecting folded proteins from a library of secondary structural elements. J Am Chem Soc 130:176-85
Debler, Erik W; Kaufmann, Gunnar F; Meijler, Michael M et al. (2008) Deeply inverted electron-hole recombination in a luminescent antibody-stilbene complex. Science 319:1232-5
Tian, Feng; Debler, Erik W; Millar, David P et al. (2006) The effects of antibodies on stilbene excited-state energetics. Angew Chem Int Ed Engl 45:7763-5
Tian, Feng; Tsao, Meng-Lin; Schultz, Peter G (2004) A phage display system with unnatural amino acids. J Am Chem Soc 126:15962-3
Yin, Jun; Mills, Jeremy H; Schultz, Peter G (2004) A catalysis-based selection for peroxidase antibodies with increased activity. J Am Chem Soc 126:3006-7
Venkateshrao, Swarnalatha; Yin, Jun; Jarzecki, Andrzej A et al. (2004) Porphyrin distortion during affinity maturation of a ferrochelatase antibody, monitored by Resonance Raman spectroscopy. J Am Chem Soc 126:16361-7
Yin, Jun; Andryski, Scott E; Beuscher 4th, Albert E et al. (2003) Structural evidence for substrate strain in antibody catalysis. Proc Natl Acad Sci U S A 100:856-61
Gildersleeve, Jeff; Varvak, Alex; Atwell, Shane et al. (2003) Development of a high-throughput screen for protein catalysts: application to the directed evolution of antibody aldolases. Angew Chem Int Ed Engl 42:5971-3
Yin, Jun; Beuscher 4th, Albert E; Andryski, Scott E et al. (2003) Structural plasticity and the evolution of antibody affinity and specificity. J Mol Biol 330:651-6

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