Abstract

The ultimate goal of the study is to attenuate the harmful hypermetabolic responses associated with burn injury. The hypotheses to be tested are: (1) Growth hormones improves donor site wound healing in burn patients and improves net protein balance in the wound and muscle; (2) propranolol, a non-selective beta-blocker, will decrease cardiac work and the rate of peripheral lipolysis and hepatic steatosis without affecting protein dynamics, and (3) the combined effects of growth hormone and propranolol will ameliorate the hypermetabolic response more effectively than either one alone by decreasing cardiac dynamics, peripheral lipolysis and hepatic steatosis and improving wound healing and protein dynamics in muscle and wound of all ages including the very young and the elderly. The studies are therefore relevant to the treatment of massively burned patients of all ages in order to shorten hospital stay, decrease their hospital morbidity and provide improved functional outcome following this devastating injury.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM056687-04
Application #
6344180
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Program Officer
Somers, Scott D
Project Start
1998-01-01
Project End
2002-06-30
Budget Start
2001-01-01
Budget End
2002-06-30
Support Year
4
Fiscal Year
2001
Total Cost
$300,651
Indirect Cost

  Institution

Name
University of Texas Medical Br Galveston
Department
Surgery
Type
Schools of Medicine
DUNS #
041367053
City
Galveston
State
TX
Country
United States
Zip Code
77555

  Publications

Capek, Karel D; Sousse, Linda E; Hundeshagen, Gabriel et al. (2018) Contemporary Burn Survival. J Am Coll Surg 226:453-463
Foncerrada, Guillermo; Culnan, Derek M; Capek, Karel D et al. (2018) Inhalation Injury in the Burned Patient. Ann Plast Surg 80:S98-S105
Bohanon, Fredrick J; Nunez Lopez, Omar; Herndon, David N et al. (2018) Burn Trauma Acutely Increases the Respiratory Capacity and Function of Liver Mitochondria. Shock 49:466-473
Cambiaso-Daniel, Janos; Boukovalas, Stafanos; Bitz, Genevieve H et al. (2018) Topical Antimicrobials in Burn Care: Part 1-Topical Antiseptics. Ann Plast Surg :
Rivas, Eric; Herndon, David N; Chapa, Martha L et al. (2018) Children with severe burns display no sex differences in exercise capacity at hospital discharge or adaptation after exercise rehabilitation training. Burns 44:1187-1194
Voigt, Charles D; Hundeshagen, Gabriel; Malagaris, Ioannis et al. (2018) Effects of a restrictive blood transfusion protocol on acute pediatric burn care: Transfusion threshold in pediatric burns. J Trauma Acute Care Surg 85:1048-1054
Cambiaso-Daniel, Janos; Parry, Ingrid; Rivas, Eric et al. (2018) Strength and Cardiorespiratory Exercise Rehabilitation for Severely Burned Patients During Intensive Care Units: A Survey of Practice. J Burn Care Res 39:897-901
Chao, Tony; Porter, Craig; Herndon, David N et al. (2018) Propranolol and Oxandrolone Therapy Accelerated Muscle Recovery in Burned Children. Med Sci Sports Exerc 50:427-435
Rivas, Eric; McEntire, Serina J; Herndon, David N et al. (2018) Resting ?-Adrenergic Blockade Does Not Alter Exercise Thermoregulation in Children With Burn Injury: A Randomized Control Trial. J Burn Care Res 39:402-412
Murton, Andrew; Bohanon, Fredrick J; Ogunbileje, John O et al. (2018) Sepsis Increases Muscle Proteolysis in Severely Burned Adults, But Does Not Impact Whole-Body Lipid or Carbohydrate Kinetics. Shock :

Showing the most recent 10 out of 186 publications