Abstract

The ultimate goal of the study is to attenuate the harmful hypermetabolic responses associated with burn injury. The hypotheses to be tested are: (1) Growth hormones improves donor site wound healing in burn patients and improves net protein balance in the wound and muscle; (2) propranolol, a non-selective beta-blocker, will decrease cardiac work and the rate of peripheral lipolysis and hepatic steatosis without affecting protein dynamics, and (3) the combined effects of growth hormone and propranolol will ameliorate the hypermetabolic response more effectively than either one alone by decreasing cardiac dynamics, peripheral lipolysis and hepatic steatosis and improving wound healing and protein dynamics in muscle and wound of all ages including the very young and the elderly. The studies are therefore relevant to the treatment of massively burned patients of all ages in order to shorten hospital stay, decrease their hospital morbidity and provide improved functional outcome following this devastating injury.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM056687-04
Application #
6344180
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Program Officer
Somers, Scott D
Project Start
1998-01-01
Project End
2002-06-30
Budget Start
2001-01-01
Budget End
2002-06-30
Support Year
4
Fiscal Year
2001
Total Cost
$300,651
Indirect Cost

  Institution

Name
University of Texas Medical Br Galveston
Department
Surgery
Type
Schools of Medicine
DUNS #
041367053
City
Galveston
State
TX
Country
United States
Zip Code
77555

  Publications

El Ayadi, Amina; Prasai, Anesh; Wang, Ye et al. (2018) ?-Adrenergic Receptor Trafficking, Degradation, and Cell Surface Expression Are Altered in Dermal Fibroblasts from Hypertrophic Scars. J Invest Dermatol 138:1645-1655
Hundeshagen, Gabriel; Collins, Vanessa N; Wurzer, Paul et al. (2018) A Prospective, Randomized, Controlled Trial Comparing the Outpatient Treatment of Pediatric and Adult Partial-Thickness Burns with Suprathel or Mepilex Ag. J Burn Care Res 39:261-267
Patel, Dipen D; Rosenberg, Marta; Rosenberg, Laura et al. (2018) Poverty, population density, and the epidemiology of burns in young children from Mexico treated at a U.S. pediatric burn facility. Burns 44:1269-1278
Ogunbileje, John O; Herndon, David N; Murton, Andrew J et al. (2018) The Role of Mitochondrial Stress in Muscle Wasting Following Severe Burn Trauma. J Burn Care Res 39:100-108
Rivas, Eric; Herndon, David N; Cambiaso-Daniel, Janos et al. (2018) Quantification of an Exercise Rehabilitation Program for Severely Burned Children: The Standard of Care at Shriners Hospitals for Children®-Galveston. J Burn Care Res 39:889-896
Guillory, Ashley N; Clayton, Robert P; Prasai, Anesh et al. (2018) Buprenorphine-Sustained Release Alters Hemodynamic Parameters in a Rat Burn Model. J Surg Res 232:154-159
?apek, Karel D; Culnan, Derek M; Desai, Manubhai H et al. (2018) Fifty Years of Burn Care at Shriners Hospitals for Children, Galveston. Ann Plast Surg 80:S90-S94
Cambiaso-Daniel, Janos; Rivas, Eric; Carson, Joshua S et al. (2018) Cardiorespiratory Capacity and Strength Remain Attenuated in Children with Severe Burn Injuries at Over 3 Years Postburn. J Pediatr 192:152-158
Rontoyanni, Victoria G; Malagaris, Ioannis; Herndon, David N et al. (2018) Skeletal Muscle Mitochondrial Function is Determined by Burn Severity, Sex, and Sepsis, and is Associated With Glucose Metabolism and Functional Capacity in Burned Children. Shock 50:141-148
Cambiaso-Daniel, Janos; Rontoyanni, Victoria G; Foncerrada, Guillermo et al. (2018) Correlation between invasive and noninvasive blood pressure measurements in severely burned children. Burns 44:1787-1791

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