Abstract

This is a new application to study the molecular mechanism of adhesion and fusion between Chlamydomonas gametes. Preliminary findings for the application were accrued through the auspices of an NSF grant.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM056778-04
Application #
6342967
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Program Officer
Chin, Jean
Project Start
1998-01-01
Project End
2003-05-31
Budget Start
2001-01-01
Budget End
2003-05-31
Support Year
4
Fiscal Year
2001
Total Cost
$176,240
Indirect Cost

  Institution

Name
University of Texas Sw Medical Center Dallas
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
City
Dallas
State
TX
Country
United States
Zip Code
75390

  Publications

Feng, Juan; Dong, Xianchi; Pinello, Jennifer et al. (2018) Fusion surface structure, function, and dynamics of gamete fusogen HAP2. Elife 7:
Angrisano, Fiona; Sala, Katarzyna A; Da, Dari F et al. (2017) Targeting the Conserved Fusion Loop of HAP2 Inhibits the Transmission of Plasmodium berghei and falciparum. Cell Rep 21:2868-2878
Fédry, Juliette; Liu, Yanjie; Péhau-Arnaudet, Gérard et al. (2017) The Ancient Gamete Fusogen HAP2 Is a Eukaryotic Class II Fusion Protein. Cell 168:904-915.e10
Cao, Muqing; Ning, Jue; Hernandez-Lara, Carmen I et al. (2015) Uni-directional ciliary membrane protein trafficking by a cytoplasmic retrograde IFT motor and ciliary ectosome shedding. Elife 4:
Liu, Yanjie; Pei, Jimin; Grishin, Nick et al. (2015) The cytoplasmic domain of the gamete membrane fusion protein HAP2 targets the protein to the fusion site in Chlamydomonas and regulates the fusion reaction. Development 142:962-71
Dresselhaus, Thomas; Snell, William J (2014) Fertilization: a sticky sperm protein in plants. Curr Biol 24:R164-6
Ning, Jue; Otto, Thomas D; Pfander, Claudia et al. (2013) Comparative genomics in Chlamydomonas and Plasmodium identifies an ancient nuclear envelope protein family essential for sexual reproduction in protists, fungi, plants, and vertebrates. Genes Dev 27:1198-215
Snell, William J (2012) Development. Plant gametes do fertilization with a twist. Science 338:1038-9
Liu, Yanjie; Misamore, Michael J; Snell, William J (2010) Membrane fusion triggers rapid degradation of two gamete-specific, fusion-essential proteins in a membrane block to polygamy in Chlamydomonas. Development 137:1473-81
Ellerman, Diego A; Pei, Jimin; Gupta, Surabhi et al. (2009) Izumo is part of a multiprotein family whose members form large complexes on mammalian sperm. Mol Reprod Dev 76:1188-99

Showing the most recent 10 out of 13 publications