Abstract

This project aims at the computer processing of functional data, representing it in simple graphical form, and modeling functional interactions among genes and proteins.
This aim will be realized through (i) automatic generation of a computer representation of regulatory networks of known genes/proteins, and (ii) stimulation and comparison of regulatory networks in different species with each other. The project is likely to benefit researchers involved in disease gene discovery projects, """"""""functional genomics""""""""analyses and most biological studies requiring analysis of complex regulatory networks.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
1R01GM061372-01A2
Application #
6399346
Study Section
Biomedical Library and Informatics Review Committee (BLR)
Program Officer
Anderson, James J
Project Start
2001-08-01
Project End
2003-07-31
Budget Start
2001-08-01
Budget End
2002-07-31
Support Year
1
Fiscal Year
2001
Total Cost
$153,266
Indirect Cost

  Institution

Name
Columbia University (N.Y.)
Department
Genetics
Type
Schools of Medicine
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032

  Publications

Yao, Lixia; Li, Ying; Ghosh, Soumitra et al. (2015) Health ROI as a measure of misalignment of biomedical needs and resources. Nat Biotechnol 33:807-11
Soldatova, Larisa N; Rzhetsky, Andrey; De Grave, Kurt et al. (2013) Representation of probabilistic scientific knowledge. J Biomed Semantics 4 Suppl 1:S7
Divoli, Anna; Mendonça, Eneida A; Evans, James A et al. (2011) Conflicting biomedical assumptions for mathematical modeling: the case of cancer metastasis. PLoS Comput Biol 7:e1002132
Balkir, Atilla Soner; Foster, Ian; Rzhetsky, Andrey (2011) A Distributed Look-up Architecture for Text Mining Applications using MapReduce. Proc Int Symp High Perform Distrib Comput 2011:
Evans, James A; Rzhetsky, Andrey (2011) Advancing science through mining libraries, ontologies, and communities. J Biol Chem 286:23659-66
Yao, Lixia; Divoli, Anna; Mayzus, Ilya et al. (2011) Benchmarking ontologies: bigger or better? PLoS Comput Biol 7:e1001055
Yao, Lixia; Evans, James A; Rzhetsky, Andrey (2010) Novel opportunities for computational biology and sociology in drug discovery. Trends Biotechnol 28:161-70
Evans, James; Rzhetsky, Andrey (2010) Philosophy of science. Machine science. Science 329:399-400
Yao, Lixia; Evans, James A; Rzhetsky, Andrey (2009) Novel opportunities for computational biology and sociology in drug discovery. Trends Biotechnol 27:531-40
Iossifov, Ivan; Rodriguez-Esteban, Raul; Mayzus, Ilya et al. (2009) Looking at cerebellar malformations through text-mined interactomes of mice and humans. PLoS Comput Biol 5:e1000559

Showing the most recent 10 out of 26 publications