Functional group organizations using covalent and non-covalent forces play an important role in almost all the biological events. Nature provides fine examples of these with the exquisite functional group organization in proteins. This proposal focuses on the design and synthesis of a new class of dendrimers that are inspired by globular proteins. Like globular proteins, these molecules are facially amphiphilic; i.e. the macromolecules have a hydrophilic exterior and a hydrophobic core. In addition, these molecules have the potential to be switched to a dendrimer with a hydrophobic exterior and hydrophilic core upon change in the environment. Study of the conformational switching processes in these dendrimers could provide valuable information on similar processes that occur in nature. The proposed dendrimers should find use as drug delivery vehicles for tumor cells. Although targeted drug delivery is not a specific goal for this proposal, experiments to obtain the proof-of-principle for the possibility will be investigated.
| Gordon, Mallory R; Zhuang, Jiaming; Ventura, Judy et al. (2018) Biodistribution Analysis of NIR-Labeled Nanogels Using in Vivo FMT Imaging in Triple Negative Human Mammary Carcinoma Models. Mol Pharm 15:1180-1191 |
| Gao, Jingjing; Liu, Xiaochi; Secinti, Hatice et al. (2018) Photoactivation of Ligands for Extrinsically and Intrinsically Triggered Disassembly of Amphiphilic Nanoassemblies. Chemistry 24:1789-1794 |
| Raghupathi, Kishore; Thayumanavan, Sankaran (2017) Nano-Armoring of Enzymes: Rational Design of Polymer-Wrapped Enzymes. Methods Enzymol 590:381-411 |
| Zhuang, Jiaming; Garzoni, Matteo; Torres, Diego Amado et al. (2017) Programmable Nanoassemblies from Non-Assembling Homopolymers Using Ad?Hoc Electrostatic Interactions. Angew Chem Int Ed Engl 56:4145-4149 |
| Munkhbat, Oyuntuya; Garzoni, Matteo; Raghupathi, Krishna R et al. (2016) Role of Aromatic Interactions in Temperature-Sensitive Amphiphilic Supramolecular Assemblies. Langmuir 32:2874-81 |
| Rangadurai, Poornima; Molla, Mijanur Rahaman; Prasad, Priyaa et al. (2016) Temporal and Triggered Evolution of Host-Guest Characteristics in Amphiphilic Polymer Assemblies. J Am Chem Soc 138:7508-11 |
| Bai, Wei; Jiang, Ziwen; Ribbe, Alexander E et al. (2016) Smart Organic Two-Dimensional Materials Based on a Rational Combination of Non-covalent Interactions. Angew Chem Int Ed Engl 55:10707-11 |
| Molla, Mijanur Rahaman; Prasad, Priyaa; Thayumanavan, S (2015) Protein-induced supramolecular disassembly of amphiphilic polypeptide nanoassemblies. J Am Chem Soc 137:7286-9 |
| Bell, Nia C; Doyle, Samantha J; Battistelli, Giulia et al. (2015) Dye Encapsulation in Polynorbornene Micelles. Langmuir 31:9707-17 |
| Ramireddy, Rajasekhar R; Prasad, P; Finne, A et al. (2015) Zwitterionic Amphiphilic Homopolymer Assemblies. Polym Chem 6:6083-6087 |
Showing the most recent 10 out of 59 publications
