Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
3R01GM066009-01A1S1
Application #
6949507
Study Section
Molecular and Cellular Biophysics Study Section (BBCA)
Program Officer
Wehrle, Janna P
Project Start
2004-04-01
Project End
2009-03-31
Budget Start
2004-04-01
Budget End
2005-03-31
Support Year
1
Fiscal Year
2004
Total Cost
$74,100
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
McDonald, Leanna R; Whitley, Matthew J; Boyer, Joshua A et al. (2013) Colocalization of fast and slow timescale dynamics in the allosteric signaling protein CheY. J Mol Biol 425:2372-81
McDonald, Leanna R; Boyer, Joshua A; Lee, Andrew L (2012) Segmental motions, not a two-state concerted switch, underlie allostery in CheY. Structure 20:1363-73
Whitley, Matthew J; Lee, Andrew L (2011) Exploring the role of structure and dynamics in the function of chymotrypsin inhibitor 2. Proteins 79:916-24
Boyer, Joshua A; Clay, Cristina J; Luce, K Scott et al. (2010) Detection of native-state nonadditivity in double mutant cycles via hydrogen exchange. J Am Chem Soc 132:8010-9
Sapienza, Paul J; Lee, Andrew L (2010) Using NMR to study fast dynamics in proteins: methods and applications. Curr Opin Pharmacol 10:723-30
Law, Anthony B; Fuentes, Ernesto J; Lee, Andrew L (2009) Conservation of side-chain dynamics within a protein family. J Am Chem Soc 131:6322-3
Whitley, Matthew J; Lee, Andrew L (2009) Frameworks for understanding long-range intra-protein communication. Curr Protein Pept Sci 10:116-27
Whitley, Matthew J; Zhang, Jun; Lee, Andrew L (2008) Hydrophobic core mutations in CI2 globally perturb fast side-chain dynamics similarly without regard to position. Biochemistry 47:8566-76
Boyer, Joshua A; Lee, Andrew L (2008) Monitoring aromatic picosecond to nanosecond dynamics in proteins via 13C relaxation: expanding perturbation mapping of the rigidifying core mutation, V54A, in eglin c. Biochemistry 47:4876-86
Clarkson, Michael W; Gilmore, Steven A; Edgell, Marshall H et al. (2006) Dynamic coupling and allosteric behavior in a nonallosteric protein. Biochemistry 45:7693-9

Showing the most recent 10 out of 13 publications