Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM067100-02
Application #
6693003
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Program Officer
Ikeda, Richard A
Project Start
2003-01-01
Project End
2006-12-31
Budget Start
2004-01-01
Budget End
2004-12-31
Support Year
2
Fiscal Year
2004
Total Cost
$285,560
Indirect Cost

  Institution

Name
University of Southern California
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
072933393
City
Los Angeles
State
CA
Country
United States
Zip Code
90089

  Publications

Guo, Jiacong; Jayaprakash, Priyamvada; Dan, Jian et al. (2017) PRAS40 Connects Microenvironmental Stress Signaling to Exosome-Mediated Secretion. Mol Cell Biol 37:
Zou, M; Bhatia, A; Dong, H et al. (2017) Evolutionarily conserved dual lysine motif determines the non-chaperone function of secreted Hsp90alpha in tumour progression. Oncogene 36:2160-2171
Dong, Hangming; Zou, Mengchen; Bhatia, Ayesha et al. (2016) Breast Cancer MDA-MB-231 Cells Use Secreted Heat Shock Protein-90alpha (Hsp90?) to Survive a Hostile Hypoxic Environment. Sci Rep 6:20605
Bhatia, Ayesha; O'Brien, Kathryn; Chen, Mei et al. (2016) Keratinocyte-Secreted Heat Shock Protein-90alpha: Leading Wound Reepithelialization and Closure. Adv Wound Care (New Rochelle) 5:176-184
Bhatia, Ayesha; O'Brien, Kathryn; Chen, Mei et al. (2016) Dual therapeutic functions of F-5 fragment in burn wounds: preventing wound progression and promoting wound healing in pigs. Mol Ther Methods Clin Dev 3:16041
Woodley, David T; Wysong, Ashley; DeClerck, Brittany et al. (2015) Keratinocyte Migration and a Hypothetical New Role for Extracellular Heat Shock Protein 90 Alpha in Orchestrating Skin Wound Healing. Adv Wound Care (New Rochelle) 4:203-212
Jayaprakash, Priyamvada; Dong, Hangming; Zou, Mengchen et al. (2015) Hsp90? and Hsp90? together operate a hypoxia and nutrient paucity stress-response mechanism during wound healing. J Cell Sci 128:1475-80
O'Brien, Kathryn; Bhatia, Ayesha; Tsen, Fred et al. (2014) Identification of the critical therapeutic entity in secreted Hsp90? that promotes wound healing in newly re-standardized healthy and diabetic pig models. PLoS One 9:e113956
Li, Wei; Tsen, Fred; Sahu, Divya et al. (2013) Extracellular Hsp90 (eHsp90) as the actual target in clinical trials: intentionally or unintentionally. Int Rev Cell Mol Biol 303:203-35
Tsen, Fred; Bhatia, Ayesha; O'Brien, Kathryn et al. (2013) Extracellular heat shock protein 90 signals through subdomain II and the NPVY motif of LRP-1 receptor to Akt1 and Akt2: a circuit essential for promoting skin cell migration in vitro and wound healing in vivo. Mol Cell Biol 33:4947-59

Showing the most recent 10 out of 14 publications