Abstract

? Rodent inbred line crosses are widely used to map genetic loci associated with complex traits. This approach has proven to be powerful for detecting quantitative trait loci (QTL) however the resolution of QTL locations is often not sufficient to identify the gene (or genes) that are involved. We propose to develop analytical methods to combine information available in two or more inbred line crosses that will help to narrow conventional confidence intervals for QTL regions. Furthermore, by exploiting high-density single nucleotide polymorphism (SNP) data that are currently being generated for the common strains of inbred mice, we expect to achieve gene level resolution of QTLs by combining data from multiple crosses. Our strategy is based on the hypothesis that the common mouse strains are derived from a limited ancestral gene pool and thus QTLs detected in multiple crosses are likely to represent shared ancestral polymorphisms. ? ?

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM070683-03
Application #
7017101
Study Section
Genome Study Section (GNM)
Program Officer
Eckstrand, Irene A
Project Start
2004-04-01
Project End
2008-03-31
Budget Start
2006-04-01
Budget End
2007-03-31
Support Year
3
Fiscal Year
2006
Total Cost
$330,057
Indirect Cost

  Institution

Name
Jackson Laboratory
Department
Type
DUNS #
042140483
City
Bar Harbor
State
ME
Country
United States
Zip Code
04609

  Publications

Gatti, D M; Weber, S N; Goodwin, N C et al. (2018) Genetic background influences susceptibility to chemotherapy-induced hematotoxicity. Pharmacogenomics J 18:319-330
Keller, Mark P; Gatti, Daniel M; Schueler, Kathryn L et al. (2018) Genetic Drivers of Pancreatic Islet Function. Genetics 209:335-356
Keele, Gregory R; Prokop, Jeremy W; He, Hong et al. (2018) Genetic Fine-Mapping and Identification of Candidate Genes and Variants for Adiposity Traits in Outbred Rats. Obesity (Silver Spring) 26:213-222
Palus, Martin; Sohrabi, Yahya; Broman, Karl W et al. (2018) A novel locus on mouse chromosome 7 that influences survival after infection with tick-borne encephalitis virus. BMC Neurosci 19:39
Morgan, Andrew P; Gatti, Daniel M; Najarian, Maya L et al. (2017) Structural Variation Shapes the Landscape of Recombination in Mouse. Genetics 206:603-619
Srivastava, Anuj; Morgan, Andrew P; Najarian, Maya L et al. (2017) Genomes of the Mouse Collaborative Cross. Genetics 206:537-556
Winter, Jean M; Gildea, Derek E; Andreas, Jonathan P et al. (2017) Mapping Complex Traits in a Diversity Outbred F1 Mouse Population Identifies Germline Modifiers of Metastasis in Human Prostate Cancer. Cell Syst 4:31-45.e6
Chesler, Elissa J; Gatti, Daniel M; Morgan, Andrew P et al. (2016) Diversity Outbred Mice at 21: Maintaining Allelic Variation in the Face of Selection. G3 (Bethesda) 6:3893-3902
Gu, Tongjun; Gatti, Daniel M; Srivastava, Anuj et al. (2016) Genetic Architectures of Quantitative Variation in RNA Editing Pathways. Genetics 202:787-98
Keller, Mark P; Paul, Pradyut K; Rabaglia, Mary E et al. (2016) The Transcription Factor Nfatc2 Regulates ?-Cell Proliferation and Genes Associated with Type 2 Diabetes in Mouse and Human Islets. PLoS Genet 12:e1006466

Showing the most recent 10 out of 54 publications