Abstract

The proposed research concerns the role of zinc and other trace elements in prenatal and neonatal mammalian development. The possible role of zinc in the fetal alcohol syndrome, and its interaction with folate, will be investigated in experimental animals. The effect of zinc deficiency on immune responsiveness will be studied. The molecular localization of zinc and copper in animal tissues and its influence on absorption and metabolism of these elements in the neonate will be investigated.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
3R01HD001743-24S1
Application #
3310136
Study Section
Nutrition Study Section (NTN)
Project Start
1977-09-01
Project End
1992-11-30
Budget Start
1988-09-01
Budget End
1989-11-30
Support Year
24
Fiscal Year
1989
Total Cost
Indirect Cost

  Institution

Name
University of California Davis
Department
Type
Earth Sciences/Resources
DUNS #
094878337
City
Davis
State
CA
Country
United States
Zip Code
95618

  Publications

Yang, Hsunhui; Keen, Carl L; Lanoue, Louise (2015) Influence of intracellular zinc on cultures of rat cardiac neural crest cells. Birth Defects Res B Dev Reprod Toxicol 104:11-22
Omata, Yo; Salvador, Gabriela A; Supasai, Suangsuda et al. (2013) Decreased zinc availability affects glutathione metabolism in neuronal cells and in the developing brain. Toxicol Sci 133:90-100
Nuttall, J R; Oteiza, P I (2012) Zinc and the ERK kinases in the developing brain. Neurotox Res 21:128-41
Oteiza, Patricia I (2012) Zinc and the modulation of redox homeostasis. Free Radic Biol Med 53:1748-59
Mackenzie, Gerardo G; Salvador, Gabriela A; Romero, Carolina et al. (2011) A deficit in zinc availability can cause alterations in tubulin thiol redox status in cultured neurons and in the developing fetal rat brain. Free Radic Biol Med 51:480-9
Adamo, Ana M; Zago, Maria P; Mackenzie, Gerardo G et al. (2010) The role of zinc in the modulation of neuronal proliferation and apoptosis. Neurotox Res 17:1-14
Aimo, Lucila; Mackenzie, Gerardo G; Keenan, Alison H et al. (2010) Gestational zinc deficiency affects the regulation of transcription factors AP-1, NF-*B and NFAT in fetal brain. J Nutr Biochem 21:1069-75
Aimo, Lucila; Cherr, Gary N; Oteiza, Patricia I (2010) Low extracellular zinc increases neuronal oxidant production through nadph oxidase and nitric oxide synthase activation. Free Radic Biol Med 48:1577-87
Hanna, Lynn A; Clegg, Michael S; Ellis-Hutchings, Robert G et al. (2010) The influence of gestational zinc deficiency on the fetal insulin-like growth factor axis in the rat. Exp Biol Med (Maywood) 235:206-14
Adamo, Ana M; Oteiza, Patricia I (2010) Zinc deficiency and neurodevelopment: the case of neurons. Biofactors 36:117-24

Showing the most recent 10 out of 98 publications