Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
2R01HD011878-19
Application #
2025006
Study Section
Special Emphasis Panel (ZRG2-REN (02))
Project Start
1979-09-30
Project End
1997-08-31
Budget Start
1997-06-01
Budget End
1997-08-31
Support Year
19
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Tufts University
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
073134835
City
Medford
State
MA
Country
United States
Zip Code
02155
Syed, V; Hecht, N B (2002) Disruption of germ cell-Sertoli cell interactions leads to spermatogenic defects. Mol Cell Endocrinol 186:155-7
Syed, V; Hecht, N B (2001) Selective loss of Sertoli cell and germ cell function leads to a disruption in sertoli cell-germ cell communication during aging in the Brown Norway rat. Biol Reprod 64:107-12
Chennathukuzhi, V M; Lefrancois, S; Morales, C R et al. (2001) Elevated levels of the polyadenylation factor CstF 64 enhance formation of the 1kB Testis brain RNA-binding protein (TB-RBP) mRNA in male germ cells. Mol Reprod Dev 58:460-9
Syed, V; Gomez, E; Hecht, N B (1999) mRNAs encoding a von Ebner's-like protein and the Huntington disease protein are induced in rat male germ cells by Sertoli cells. J Biol Chem 274:10737-42
Syed, V; Gomez, E; Hecht, N B (1999) Messenger ribonucleic acids encoding a serotonin receptor and a novel gene are induced in Sertoli cells by a secreted factor(s) from male rat meiotic germ cells. Endocrinology 140:5754-60
Syed, V; Hecht, N B (1998) Rat pachytene spermatocytes down-regulate a polo-like kinase and up-regulate a thiol-specific antioxidant protein, whereas sertoli cells down-regulate a phosphodiesterase and up-regulate an oxidative stress protein after exposure to methoxyethanol and met Endocrinology 139:3503-11
Gu, W; Hecht, N B (1997) The enzymatic activity of Cu/Zn superoxide dismutase does not fluctuate in mouse spermatogenic cells despite mRNA changes. Exp Cell Res 232:371-5
Yiu, G K; Murray, M T; Hecht, N B (1997) Deoxyribonucleic acid-protein interactions associated with transcriptional initiation of the mouse testis-specific cytochrome c gene. Biol Reprod 56:1439-49
Yiu, G K; Hecht, N B (1997) Novel testis-specific protein-DNA interactions activate transcription of the mouse protamine 2 gene during spermatogenesis. J Biol Chem 272:26926-33
Choi, Y C; Aizawa, A; Hecht, N B (1997) Genomic analysis of the mouse protamine 1, protamine 2, and transition protein 2 gene cluster reveals hypermethylation in expressing cells. Mamm Genome 8:317-23

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