Abstract

The over-all objective of this proposal is to elucidate the role of the decidual tissue in the regulation of corpus luteum function in pregnant and pseudopregnant rats. The first approach, using transplantation and radioimmunoassay, will be determine whether the decidual tissue (DT) of pregnant rats, like the DT of pseudopregnant animals, sustain progesterone synthesis in the absence of prolactin. Using hypophysectomized animals we will determine whether the luteotropic effect of the decidual tissue is related to the presence of LH or estrogen. The possibility that the decidual tissue stimulates, like prolactin, the generation of both LH and estradiol receptor will then be investigated using a radioreceptor technique. Finally, we will determine whether the DT-hormone bind, as does rat placental lactogen to the same receptor site than prolactin, and if so the levels of the DT-hormone will be measured in the DT and in the serum.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
2R01HD012356-07A1
Application #
3311872
Study Section
Reproductive Biology Study Section (REB)
Project Start
1978-12-01
Project End
1989-03-31
Budget Start
1986-04-01
Budget End
1987-03-31
Support Year
7
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
University of Illinois at Chicago
Department
Type
Overall Medical
DUNS #
121911077
City
Chicago
State
IL
Country
United States
Zip Code
60612

  Publications

Le, Jamie A; Wilson, Heather M; Shehu, Aurora et al. (2012) Generation of mice expressing only the long form of the prolactin receptor reveals that both isoforms of the receptor are required for normal ovarian function. Biol Reprod 86:86
Shehu, Aurora; Albarracin, Constance; Devi, Y Sangeeta et al. (2011) The stimulation of HSD17B7 expression by estradiol provides a powerful feed-forward mechanism for estradiol biosynthesis in breast cancer cells. Mol Endocrinol 25:754-66
Le, J A; Wilson, H M; Shehu, A et al. (2011) Prolactin activation of the long form of its cognate receptor causes increased visceral fat and obesity in males as shown in transgenic mice expressing only this receptor subtype. Horm Metab Res 43:931-7
Devi, Y Sangeeta; Seibold, Anita M; Shehu, Aurora et al. (2011) Inhibition of MAPK by prolactin signaling through the short form of its receptor in the ovary and decidua: involvement of a novel phosphatase. J Biol Chem 286:7609-18
Devi, Y Sangeeta; Shehu, Aurora; Halperin, Julia et al. (2009) Prolactin signaling through the short isoform of the mouse prolactin receptor regulates DNA binding of specific transcription factors, often with opposite effects in different reproductive issues. Reprod Biol Endocrinol 7:87
Devi, Y Sangeeta; Shehu, Aurora; Stocco, Carlos et al. (2009) Regulation of transcription factors and repression of Sp1 by prolactin signaling through the short isoform of its cognate receptor. Endocrinology 150:3327-35
Halperin, Julia; Devi, Sangeeta Y; Elizur, Shai et al. (2008) Prolactin signaling through the short form of its receptor represses forkhead transcription factor FOXO3 and its target gene galt causing a severe ovarian defect. Mol Endocrinol 22:513-22
Li, Feixue; Devi, Y Sangeeta; Bao, Lei et al. (2008) Involvement of cyclin D3, CDKN1A (p21), and BIRC5 (Survivin) in interleukin 11 stimulation of decidualization in mice. Biol Reprod 78:127-33
Bao, Lei; Tessier, Christian; Prigent-Tessier, Anne et al. (2007) Decidual prolactin silences the expression of genes detrimental to pregnancy. Endocrinology 148:2326-34
Bao, Lei; Devi, Sangeeta; Bowen-Shauver, Jennifer et al. (2006) The role of interleukin-11 in pregnancy involves up-regulation of alpha2-macroglobulin gene through janus kinase 2-signal transducer and activator of transcription 3 pathway in the decidua. Mol Endocrinol 20:3240-50

Showing the most recent 10 out of 51 publications