Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD016550-10
Application #
3313746
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1990-12-27
Project End
1992-06-30
Budget Start
1991-12-01
Budget End
1992-06-30
Support Year
10
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Rockefeller University
Department
Type
Other Domestic Higher Education
DUNS #
071037113
City
New York
State
NY
Country
United States
Zip Code
10065
Atkins, Annette R; Gallin, Warren J; Owens, Geoffrey C et al. (2004) Neural cell adhesion molecule (N-CAM) homophilic binding mediated by the two N-terminal Ig domains is influenced by intramolecular domain-domain interactions. J Biol Chem 279:49633-43
Mistry, Sanjay K; Keefer, Edward W; Cunningham, Bruce A et al. (2002) Cultured rat hippocampal neural progenitors generate spontaneously active neural networks. Proc Natl Acad Sci U S A 99:1621-6
Little, E B; Crossin, K L; Krushel, L A et al. (2001) A short segment within the cytoplasmic domain of the neural cell adhesion molecule (N-CAM) is essential for N-CAM-induced NF-kappa B activity in astrocytes. Proc Natl Acad Sci U S A 98:2238-43
Atkins, A R; Chung, J; Deechongkit, S et al. (2001) Solution structure of the third immunoglobulin domain of the neural cell adhesion molecule N-CAM: can solution studies define the mechanism of homophilic binding? J Mol Biol 311:161-72
Choi, J; Krushel, L A; Crossin, K L (2001) NF-kappaB activation by N-CAM and cytokines in astrocytes is regulated by multiple protein kinases and redox modulation. Glia 33:45-56
Amoureux, M C; Cunningham, B A; Edelman, G M et al. (2000) N-CAM binding inhibits the proliferation of hippocampal progenitor cells and promotes their differentiation to a neuronal phenotype. J Neurosci 20:3631-40
Atkins, A R; Osborne, M J; Lashuel, H A et al. (1999) Association between the first two immunoglobulin-like domains of the neural cell adhesion molecule N-CAM. FEBS Lett 451:162-8
Krushel, L A; Cunningham, B A; Edelman, G M et al. (1999) NF-kappaB activity is induced by neural cell adhesion molecule binding to neurons and astrocytes. J Biol Chem 274:2432-9
Little, E B; Edelman, G M; Cunningham, B A (1998) Palmitoylation of the cytoplasmic domain of the neural cell adhesion molecule N-CAM serves as an anchor to cellular membranes. Cell Adhes Commun 6:415-30
Krushel, L A; Tai, M H; Cunningham, B A et al. (1998) Neural cell adhesion molecule (N-CAM) domains and intracellular signaling pathways involved in the inhibition of astrocyte proliferation. Proc Natl Acad Sci U S A 95:2592-6

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