Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
3R01HD016806-10S1
Application #
3313959
Study Section
Reproductive Biology Study Section (REB)
Project Start
1984-04-01
Project End
1995-06-30
Budget Start
1993-07-01
Budget End
1994-06-30
Support Year
10
Fiscal Year
1993
Total Cost
Indirect Cost
Name
University of Virginia
Department
Type
Schools of Medicine
DUNS #
001910777
City
Charlottesville
State
VA
Country
United States
Zip Code
22904
Veldhuis, Johannes D; Zhang, George; Garmey, James C (2002) Troglitazone, an insulin-sensitizing thiazolidinedione, represses combined stimulation by LH and insulin of de novo androgen biosynthesis by thecal cells in vitro. J Clin Endocrinol Metab 87:1129-33
Schoppee, Pamela D; Garmey, James C; Veldhuis, Johannes D (2002) Putative activation of the peroxisome proliferator-activated receptor gamma impairs androgen and enhances progesterone biosynthesis in primary cultures of porcine theca cells. Biol Reprod 66:190-8
Sekar, N; Veldhuis, J D (2001) Concerted transcriptional activation of the low density lipoprotein receptor gene by insulin and luteinizing hormone in cultured porcine granulosa-luteal cells: possible convergence of protein kinase a, phosphatidylinositol 3-kinase, and mitogen-activated Endocrinology 142:2921-8
Sekar, N; Garmey, J C; Veldhuis, J D (2000) Mechanisms underlying the steroidogenic synergy of insulin and luteinizing hormone in porcine granulosa cells: joint amplification of pivotal sterol-regulatory genes encoding the low-density lipoprotein (LDL) receptor, steroidogenic acute regulatory (stAR Mol Cell Endocrinol 159:25-35
Garmey, J C; Schnorr, J A; Bruns, M E et al. (2000) Expression of parathyroid hormone-related peptide (PTH-rp) and its receptorin the porcine ovary: regulation by transforming growth factor-beta and possible paracrine effects of granulosa cell PTH-rp secretion on theca cells. Biol Reprod 62:334-9
Sekar, N; Lavoie, H A; Veldhuis, J D (2000) Concerted regulation of steroidogenic acute regulatory gene expression by luteinizing hormone and insulin (or insulin-like growth factor I) in primary cultures of porcine granulosa-luteal cells. Endocrinology 141:3983-92
Zhang, G; Garmey, J C; Veldhuis, J D (2000) Interactive stimulation by luteinizing hormone and insulin of the steroidogenic acute regulatory (StAR) protein and 17alpha-hydroxylase/17,20-lyase (CYP17) genes in porcine theca cells. Endocrinology 141:2735-42
Garmey, J C; Guthrie, H D; Garrett, W M et al. (2000) Localization and expression of low-density lipoprotein receptor, steroidogenic acute regulatory protein, cytochrome P450 side-chain cleavage and P450 17-alpha-hydroxylase/C17-20 lyase in developing swine follicles: in situ molecular hybridization and immu Mol Cell Endocrinol 170:57-65
Flores, J A; Garmey, J C; Lahav, M et al. (1999) Mechanisms underlying endothelin's inhibition of FSH-stimulated progesterone production by ovarian granulosa cells. Mol Cell Endocrinol 156:169-78
Flores, J A; Aguirre, C; Sharma, O P et al. (1998) Luteinizing hormone (LH) stimulates both intracellular calcium ion ([Ca2+]i) mobilization and transmembrane cation influx in single ovarian (granulosa) cells: recruitment as a cellular mechanism of LH-[Ca2+]i dose response. Endocrinology 139:3606-12

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