Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
2R01HD018201-11A2
Application #
2025081
Study Section
Reproductive Biology Study Section (REB)
Project Start
1983-04-01
Project End
2001-08-31
Budget Start
1996-09-30
Budget End
1997-08-31
Support Year
11
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Duke University
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705
Tomes, C N; Roggero, C M; De Blas, G et al. (2004) Requirement of protein tyrosine kinase and phosphatase activities for human sperm exocytosis. Dev Biol 265:399-415
Kiefer, Susan McLeskey; Saling, Patricia (2002) Proteolytic processing of human zona pellucida proteins. Biol Reprod 66:407-14
Tomes, C N; Carballada, R; Moses, D F et al. (1998) Treatment of human spermatozoa with seminal plasma inhibits protein tyrosine phosphorylation. Mol Hum Reprod 4:17-25
Carballada, R; Saling, P M (1997) Regulation of mouse epididymal epithelium in vitro by androgens, temperature and fibroblasts. J Reprod Fertil 110:171-81
Tomes, C N; McMaster, C R; Saling, P M (1996) Activation of mouse sperm phosphatidylinositol-4,5 bisphosphate-phospholipase C by zona pellucida is modulated by tyrosine phosphorylation. Mol Reprod Dev 43:196-204
Leyton, L; Tomes, C; Saling, P (1995) LL95 monoclonal antibody mimics functional effects of ZP3 on mouse sperm: evidence that the antigen recognized is not hexokinase. Mol Reprod Dev 42:347-58
Burks, D J; Carballada, R; Moore, H D et al. (1995) Interaction of a tyrosine kinase from human sperm with the zona pellucida at fertilization. Science 269:83-6
Beebe, S J; Leyton, L; Burks, D et al. (1992) Recombinant mouse ZP3 inhibits sperm binding and induces the acrosome reaction. Dev Biol 151:48-54
Wolf, D E; McKinnon, C A; Leyton, L et al. (1992) Protein dynamics in sperm membranes: implications for sperm function during gamete interaction. Mol Reprod Dev 33:228-34
Saling, P M (1991) How the egg regulates sperm function during gamete interaction: facts and fantasies. Biol Reprod 44:246-51

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