The proposed research continues a study the process of arousal and attention during development and its influence on later perceptual, cognitive, and autoregulatory systems, in both normal infants and infants at risk for poor outcome due to CNS injury.
The specific aims are to determine: 1) the early neural substrates of arousal and attention; 2) the interaction of arousal and attention across development; and 3) the consequences of developmental transitions in arousal and attention for perceptual, cognitive, and autoregulatory development; and to 4) validate an assessment of early arousal-modulated attention (AMA) as a predictor of atypical development, with particular emphasis on autoregulatory outcomes. The design is a prospective, two tiered, longitudinal study of two cohorts: 336 newly recruited infants from the NICU followed from birth to 34 months, and 285 children previously studied as infants, and followed in this project from 34 to 60 months of age. Hypotheses will be tested using a battery of assessments at follow-up ages (4, 10, 16, 25, and 34 months for the new cohort and 34, 42, 51, and 60 months for the existing cohort). Emphasis is on neurophysiologic measures (visual and auditory evoked potentials) in the newborn period, behavioral measures of autoregulatory and AMA processes during the 1st year, and higher order executive control measures at later ages, in order to understand the antecedents and consequences of these processes at each period. Results will be analyzed using multivariate, multilevel statistical procedures including GEE and SEM, as appropriate.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
2R01HD021784-13A2
Application #
6140486
Study Section
Special Emphasis Panel (ZRG1-BBBP-6 (01))
Program Officer
Hanson, James W
Project Start
1986-04-01
Project End
2005-03-31
Budget Start
2000-07-15
Budget End
2001-06-30
Support Year
13
Fiscal Year
2000
Total Cost
$489,010
Indirect Cost
Name
Institute for Basic Research in Dev Disabil
Department
Type
DUNS #
167205090
City
Staten Island
State
NY
Country
United States
Zip Code
10314
Kittler, Phyllis M; Brooks, Patricia J; Rossi, Vanessa et al. (2013) Neonatal Intensive-Care Unit Graduates Show Persistent Difficulties in an Intra-Dimensional Shift Card Sort. J Cogn Dev 14:633-650
Kittler, Phyllis M; Gardner, Judith M; Lennon, Elizabeth M et al. (2011) The development of selective attention and inhibition in NICU graduates during the preschool years. Dev Neuropsychol 36:1003-17
Karmel, Bernard Z; Gardner, Judith M; Meade, Lauren Swensen et al. (2010) Early medical and behavioral characteristics of NICU infants later classified with ASD. Pediatrics 126:457-67
Kittler, Phyllis M; Phan, Ha T T; Gardner, Judith M et al. (2009) Auditory brainstem evoked responses in newborns with Down syndrome. Am J Intellect Dev Disabil 114:393-400
Karmel, Bernard Z; Gardner, Judith M (2005) Neurobehavioral assessment in the neonatal period--the impact of Ferenc Katona. Ideggyogy Sz 58:315-23
Geva, R; Gardner, J M; Karmel, B Z (1999) Feeding-based arousal effects on visual recognition memory in early infancy. Dev Psychol 35:640-50
Freedland, R L; Karmel, B Z; Gardner, J M et al. (1998) Prenatal cocaine exposure and stimulus-seeking behaviors during the first year of life. Ann N Y Acad Sci 846:386-90
Karmel, B Z; Gardner, J M; Freedland, R L (1998) Neonatal neurobehavioral assessment Bayley I and II scores of CNS-injured and cocaine-exposed infants. Ann N Y Acad Sci 846:391-5
Karmel, B Z; Gardner, J M (1996) Prenatal cocaine exposure effects on arousal-modulated attention during the neonatal period. Dev Psychobiol 29:463-80
Karmel, B Z; Gardner, J M; Freedland, R L (1996) Arousal-modulated attention at four months as a function of intrauterine cocaine exposure and central nervous system injury. J Pediatr Psychol 21:821-32

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