Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD022196-12
Application #
2198478
Study Section
Reproductive Endocrinology Study Section (REN)
Project Start
1990-05-01
Project End
1999-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
12
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Iowa
Department
Physiology
Type
Schools of Medicine
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242

  Publications

Charmandari, E; Guan, R; Zhang, M et al. (2016) Misfolding Ectodomain Mutations of the Lutropin Receptor Increase Efficacy of Hormone Stimulation. Mol Endocrinol 30:62-76
Stilley, Julie A W; Christensen, Debora E; Dahlem, Kristin B et al. (2014) FSH receptor (FSHR) expression in human extragonadal reproductive tissues and the developing placenta, and the impact of its deletion on pregnancy in mice. Biol Reprod 91:74
Stilley, Julie A; Guan, Rongbin; Duffy, Diane M et al. (2014) Signaling through FSH receptors on human umbilical vein endothelial cells promotes angiogenesis. J Clin Endocrinol Metab 99:E813-20
Feng, Xiuyan; Zhang, Meilin; Guan, Rongbin et al. (2013) Heterodimerization between the lutropin and follitropin receptors is associated with an attenuation of hormone-dependent signaling. Endocrinology 154:3925-30
Segaloff, Deborah L (2012) Regulatory processes governing the cell surface expression of LH and FSH receptors. Subcell Biochem 63:113-29
Zhang, Meilin; Guan, Rongbin; Segaloff, Deborah L (2012) Revisiting and questioning functional rescue between dimerized LH receptor mutants. Mol Endocrinol 26:655-68
Newton, Claire L; Whay, Adele M; McArdle, Craig A et al. (2011) Rescue of expression and signaling of human luteinizing hormone G protein-coupled receptor mutants with an allosterically binding small-molecule agonist. Proc Natl Acad Sci U S A 108:7172-6
Guan, Rongbin; Wu, Xueqing; Feng, Xiuyan et al. (2010) Structural determinants underlying constitutive dimerization of unoccupied human follitropin receptors. Cell Signal 22:247-56
Peltoketo, Hellevi; Strauss, Leena; Karjalainen, Riikka et al. (2010) Female mice expressing constitutively active mutants of FSH receptor present with a phenotype of premature follicle depletion and estrogen excess. Endocrinology 151:1872-83
Segaloff, Deborah L (2010) Constitutive activity of the lutropin receptor and its allosteric modulation by receptor heterodimerization. Methods Enzymol 484:231-52

Showing the most recent 10 out of 68 publications