When females of the DDK inbred mouse strain are mated to males of many other inbred strains, the vast majority of the resulting embryos die during preimplantation development. The reciprocal matings, between DDK males and females of other inbred strains are fully viable. The maternal and paternal components of this lethal trait segregate as two closely-linked loci. Over the last three years, we have succeeded in localizing these genes to a small area (approximately 300 kilobases) of mouse chromosome 11. The isolation of these genes should allow a determination of how the maternal and paternal genes interact to result in the death of preimplantation embryos and, perhaps, how this interaction results in the preferential segregation of chromosomes 11 (meiotic drive) among heterozygous females. The isolation of these genes will also allow an investigation of how the non-Mendelian, parental-origin dependent, transmission of this trait is achieved.
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| Han, Zhiming; Mtango, Namdori R; Patel, Bela G et al. (2008) Hybrid vigor and transgenerational epigenetic effects on early mouse embryo phenotype. Biol Reprod 79:638-48 |
| Bell, Timothy A; de la Casa-Esperon, Elena; Doherty, Heather E et al. (2006) The paternal gene of the DDK syndrome maps to the Schlafen gene cluster on mouse chromosome 11. Genetics 172:411-23 |
| Gao, Shaorong; Wu, Guangming; Han, Zhiming et al. (2005) Recapitulation of the ovum mutant (Om) phenotype and loss of Om locus polarity in cloned mouse embryos. Biol Reprod 72:487-91 |
| Ideraabdullah, Folami Y; de la Casa-Esperon, Elena; Bell, Timothy A et al. (2004) Genetic and haplotype diversity among wild-derived mouse inbred strains. Genome Res 14:1880-7 |
| de La Casa-Esperon, Elena; Loredo-Osti, J Concepcion; Pardo-Manuel de Villena, Fernando et al. (2002) X chromosome effect on maternal recombination and meiotic drive in the mouse. Genetics 161:1651-9 |
| Pardo-Manuel de Villena, F; Sapienza, C (2001) Transmission ratio distortion in offspring of heterozygous female carriers of Robertsonian translocations. Hum Genet 108:31-6 |
| Pardo-Manuel de Villena, F; Sapienza, C (2001) Recombination is proportional to the number of chromosome arms in mammals. Mamm Genome 12:318-22 |
| Pardo-Manuel de Villena, F; Sapienza, C (2001) Transmission of Robertsonian chromosomes through human female meiosis. Cytogenet Cell Genet 92:342-4 |
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