Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL013645-25
Application #
2214765
Study Section
Toxicology Subcommittee 2 (TOX)
Project Start
1979-02-01
Project End
2000-02-29
Budget Start
1996-03-01
Budget End
1997-02-28
Support Year
25
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Utah
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112

  Publications

Reilly, Christopher A; Henion, Fred; Bugni, Tim S et al. (2013) Reactive intermediates produced from the metabolism of the vanilloid ring of capsaicinoids by p450 enzymes. Chem Res Toxicol 26:55-66
Zhou, Xin; D'Agostino, Jaime; Li, Lei et al. (2012) Respective roles of CYP2A5 and CYP2F2 in the bioactivation of 3-methylindole in mouse olfactory mucosa and lung: studies using Cyp2a5-null and Cyp2f2-null mouse models. Drug Metab Dispos 40:642-7
Behrendorff, James B Y H; Moore, Chad D; Kim, Keon-Hee et al. (2012) Directed evolution reveals requisite sequence elements in the functional expression of P450 2F1 in Escherichia coli. Chem Res Toxicol 25:1964-74
Weems, Jessica M; Lamb, John G; D'Agostino, Jaime et al. (2010) Potent mutagenicity of 3-methylindole requires pulmonary cytochrome P450-mediated bioactivation: a comparison to the prototype cigarette smoke mutagens B(a)P and NNK. Chem Res Toxicol 23:1682-90
Weems, Jessica M; Yost, Garold S (2010) 3-Methylindole metabolites induce lung CYP1A1 and CYP2F1 enzymes by AhR and non-AhR mechanisms, respectively. Chem Res Toxicol 23:696-704
D'Agostino, Jaime; Zhuo, Xiaoliang; Shadid, Mohammad et al. (2009) The pneumotoxin 3-methylindole is a substrate and a mechanism-based inactivator of CYP2A13, a human cytochrome P450 enzyme preferentially expressed in the respiratory tract. Drug Metab Dispos 37:2018-27
Sun, Hao; Moore, Chad; Dansette, Patrick M et al. (2009) Dehydrogenation of the indoline-containing drug 4-chloro-N-(2-methyl-1-indolinyl)-3-sulfamoylbenzamide (indapamide) by CYP3A4: correlation with in silico predictions. Drug Metab Dispos 37:672-84
Weems, Jessica M; Cutler, Ned S; Moore, Chad et al. (2009) 3-Methylindole is mutagenic and a possible pulmonary carcinogen. Toxicol Sci 112:59-67
Kartha, Jaya S; Skordos, Konstantine W; Sun, Hao et al. (2008) Single mutations change CYP2F3 from a dehydrogenase of 3-methylindole to an oxygenase. Biochemistry 47:9756-70
Sun, Hao; Yost, Garold S (2008) Metabolic activation of a novel 3-substituted indole-containing TNF-alpha inhibitor: dehydrogenation and inactivation of CYP3A4. Chem Res Toxicol 21:374-85

Showing the most recent 10 out of 63 publications